gene

IRF7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections
0Hypotheses
0Analyses
50Outgoing
17Incoming

Summary

IRF7 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with Cancer, Carcinoma, Inflammation. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIRF7
Chromosome11p15.5
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight55 kDa
Amino Acids503 aa
Exons9
PathwaysImmune Response, Inflammasome, Jak-Stat, Pyroptosis
NCBI Gene ID3665
GeneCardsIRF7
Human Protein AtlasIRF7
DiseaseMechanism
Alzheimer's DiseaseChronic inflammation, IFN signature
Parkinson's DiseaseMicroglial activation
ALSNeuroinflammation
Viral EncephalitisAntiviral response
Associated Diseasesneurodegeneration
InteractionsSTING1, CGAS, IFNAR1, STING, APOE, TNF
KG Connections100 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

IRF7 Gene

gene · 542 words

cGAS-STING Signaling in Parkinson's Disease

mechanism · 3408 words

IL28B (Interleukin 28B)

gene · 3405 words

Interferon Signaling in Neurodegeneration

mechanism · 2944 words

ZBP1 (Z-DNA Binding Protein 1)

gene · 2823 words

S100 Protein Signaling Pathway in Neurodegeneration

mechanism · 2588 words

Pathway Diagram

graph TD
    IRF7["<b>IRF7</b>"]
    Carcinoma{"Carcinoma"}
    IRF7 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    IRF7 -->|"activates"| Cancer
    Tumor{"Tumor"}
    IRF7 -->|"activates"| Tumor
    Inflammation{"Inflammation"}
    IRF7 -->|"activates"| Inflammation
    Ms{"Ms"}
    IRF7 -->|"expressed in"| Ms
    INFLAMMATION["INFLAMMATION"]
    IRF7 -->|"activates"| INFLAMMATION
    CANCER["CANCER"]
    IRF7 -->|"activates"| CANCER
    STING["STING"]
    IRF7 -->|"regulates"| STING
    CGAS["CGAS"]
    IRF7 -->|"regulates"| CGAS
    NF__B["NF-KappaB"]
    IRF7 -->|"expressed in"| NF__B
    FERROPTOSIS["FERROPTOSIS"]
    IRF7 -->|"expressed in"| FERROPTOSIS
    PPARGC1A["PPARGC1A"]
    IRF7 -->|"expressed in"| PPARGC1A
    RPS18["RPS18"]
    RPS18 -->|"regulates"| IRF7
    JAK2["JAK2"]
    JAK2 -->|"activates"| IRF7
    RELA["RELA"]
    RELA -->|"expressed in"| IRF7
    MYC["MYC"]
    MYC -->|"expressed in"| IRF7
    SP1["SP1"]
    SP1 -->|"expressed in"| IRF7
    style IRF7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

TargetRelationTypeStr
Inflammationactivatesdisease0.75
INFLAMMATIONactivatesgene0.70
Carcinomaactivatesdisease0.65
Canceractivatesdisease0.65
Tumoractivatesdisease0.65

Incoming (17)

SourceRelationTypeStr
RPS18regulatesgene0.80
JAK2activatesgene0.60
RELAexpressed_ingene0.60
MYCexpressed_ingene0.60
SP1expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found