Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRF7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IRF7 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with Cancer, Carcinoma, Inflammation. Connected to 35 entities in the SciDEX knowledge graph.
| Gene Symbol | IRF7 |
| Chromosome | 11p15.5 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 55 kDa |
| Amino Acids | 503 aa |
| Exons | 9 |
| Pathways | Immune Response, Inflammasome, Jak-Stat, Pyroptosis |
| NCBI Gene ID | 3665 |
| GeneCards | IRF7 |
| Human Protein Atlas | IRF7 |
| Disease | Mechanism |
| Alzheimer's Disease | Chronic inflammation, IFN signature |
| Parkinson's Disease | Microglial activation |
| ALS | Neuroinflammation |
| Viral Encephalitis | Antiviral response |
| Associated Diseases | neurodegeneration |
| Interactions | STING1, CGAS, IFNAR1, STING, APOE, TNF |
| KG Connections | 100 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
IRF7["<b>IRF7</b>"]
Carcinoma{"Carcinoma"}
IRF7 -->|"activates"| Carcinoma
Cancer{"Cancer"}
IRF7 -->|"activates"| Cancer
Tumor{"Tumor"}
IRF7 -->|"activates"| Tumor
Inflammation{"Inflammation"}
IRF7 -->|"activates"| Inflammation
Ms{"Ms"}
IRF7 -->|"expressed in"| Ms
INFLAMMATION["INFLAMMATION"]
IRF7 -->|"activates"| INFLAMMATION
CANCER["CANCER"]
IRF7 -->|"activates"| CANCER
STING["STING"]
IRF7 -->|"regulates"| STING
CGAS["CGAS"]
IRF7 -->|"regulates"| CGAS
NF__B["NF-KappaB"]
IRF7 -->|"expressed in"| NF__B
FERROPTOSIS["FERROPTOSIS"]
IRF7 -->|"expressed in"| FERROPTOSIS
PPARGC1A["PPARGC1A"]
IRF7 -->|"expressed in"| PPARGC1A
RPS18["RPS18"]
RPS18 -->|"regulates"| IRF7
JAK2["JAK2"]
JAK2 -->|"activates"| IRF7
RELA["RELA"]
RELA -->|"expressed in"| IRF7
MYC["MYC"]
MYC -->|"expressed in"| IRF7
SP1["SP1"]
SP1 -->|"expressed in"| IRF7
style IRF7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 0.75 |
| INFLAMMATION | activates | gene | 0.70 |
| Carcinoma | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Dementia | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Pyroptosis | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| STING | regulates | gene | 0.60 |
| CGAS | regulates | gene | 0.60 |
| PPARGC1A | expressed_in | gene | 0.60 |
| ATF4 | expressed_in | gene | 0.60 |
| JUN | expressed_in | gene | 0.60 |
| NFKB1 | expressed_in | gene | 0.60 |
| STING1 | activates | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| IFNAR1 | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| IRF3 | activates | gene | 0.60 |
| ISG15 | associated_with | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| STING | expressed_in | gene | 0.60 |
| IRF3 | expressed_in | gene | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| CD68 | expressed_in | gene | 0.60 |
| CSF1R | activates | gene | 0.60 |
| NLRP3 | regulates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| FERROPTOSIS | expressed_in | gene | 0.60 |
| Ferroptosis | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Oxidative Phosphorylation | expressed_in | pathway | 0.60 |
| JAK | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| CGAS-STING | activates | gene | 0.60 |
| Jak-Stat | activates | pathway | 0.60 |
| Pyroptosis | activates | pathway | 0.60 |
| IL-6 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RPS18 | regulates | gene | 0.80 |
| JAK2 | activates | gene | 0.60 |
| RELA | expressed_in | gene | 0.60 |
| MYC | expressed_in | gene | 0.60 |
| SP1 | expressed_in | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| TLR4 | regulates | gene | 0.60 |
| PYROPTOSIS | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| CGAS-STING | activates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| CYTOKINES | inhibits | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| CCL2 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||