SORL1

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SORL1 (Sortilin-Related Receptor 1) - key AD risk gene involved in APP trafficking and retromer function

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graph TD
    SORL1["<b>SORL1</b>"]
    Alzheimer_s_disease{"Alzheimer's disease"}
    SORL1 -->|"associated with"| Alzheimer_s_disease
    Alzheimer{"Alzheimer"}
    SORL1 -->|"associated with"| Alzheimer
    Ms{"Ms"}
    SORL1 -->|"associated with"| Ms
    Als{"Als"}
    SORL1 -->|"associated with"| Als
    Parkinson{"Parkinson"}
    SORL1 -->|"interacts with"| Parkinson
    SORL1 -->|"interacts with"| Alzheimer
    SORL1 -->|"interacts with"| Ms
    Neurodegeneration{"Neurodegeneration"}
    SORL1 -->|"interacts with"| Neurodegeneration
    LRP12["LRP12"]
    SORL1 -->|"associated with"| LRP12
    Cholesterol(["Cholesterol"])
    SORL1 -->|"associated with"| Cholesterol
    Lipid_Metabolism(["Lipid Metabolism"])
    SORL1 -->|"associated with"| Lipid_Metabolism
    BACE1["BACE1"]
    SORL1 -->|"interacts with"| BACE1
    RPS18["RPS18"]
    RPS18 -->|"downregulates"| SORL1
    SOAT1["SOAT1"]
    SOAT1 -->|"associated with"| SORL1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| SORL1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| SORL1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"interacts with"| SORL1
    PSEN1["PSEN1"]
    PSEN1 -->|"interacts with"| SORL1
    PRKN["PRKN"]
    PRKN -->|"interacts with"| SORL1
    TREM2["TREM2"]
    TREM2 -->|"associated with"| SORL1
    PLCG2["PLCG2"]
    PLCG2 -->|"associated with"| SORL1
    ABCA7["ABCA7"]
    ABCA7 -->|"associated with"| SORL1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| SORL1
    LDLR["LDLR"]
    LDLR -->|"associated with"| SORL1
    style SORL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0