gene

RPS26

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RPS26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RPS26 is a component of the 40S ribosomal subunit involved in protein synthesis, ribosome biogenesis, and p53 regulation. Mutations cause Diamond-Blackfan anemia; dysregulation linked to neurodegeneration in AD/PD.

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🧬 Gene Info

Gene Symbol	RPS26
Full Name	Ribosomal Protein S26
Chromosome	12p13.31
Protein Type	Gene
Function	is a component of the 40S ribosomal subunit and plays essential roles in protein synthesis, ribosome biogenesis, and cellular stress response[@rps26_structure_2020].
Molecular Weight	13 kDa
Amino Acids	119 aa
GeneCards	RPS26
Human Protein Atlas	RPS26
mRNA recruitment	RPS26 contributes to the proper positioning of the 43S complex on the 5' cap structure
Scanning optimization	The protein helps maintain the scanning competence of the 40S subunit
Start codon recognition	RPS26 participates in the final steps of AUG codon recognition
Reduced ribosomal protein expression	Post-mortem brain analysis of AD patients shows decreased RPS26 and other ribosomal protein levels in vulnerable regions including hippocampus and entorhinal cortex
Translation impairment	Global protein synthesis is reduced in AD brain, correlating with cognitive decline
Ribosomal stress response	Activation of the p53-mediated stress response has been observed in AD neurons, potentially linked to ribosomal dysfunction
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RPS26 — Ribosomal Protein S26

gene · 1680 words

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RPS26 Protein

protein · 663 words

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Pathway Diagram

graph TD
    RPS26["RPS26"]
    neurodegeneration["neurodegeneration"]
    RPS26 -->|"implicated_in"| neurodegeneration
    style RPS26 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RPS26 in their description or question text

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