Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RRAS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive coverage of RRAS3 (GEM/Kir) in neuronal calcium signaling, synaptic plasticity, neuroprotection, and potential roles in Alzheimer's and Parkinson's disease
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| Gene Symbol | RRAS3 |
| Full Name | Related RAS Virus (R-Ras) Family Member 3 |
| Aliases | GEM/Kir |
| Chromosome | 11q12.1 |
| Function | is a member of the Ras GTPase superfamily expressed predominantly in neuronal tissues. |
| Primary Expression | the brain, particularly in the hippocampus and cerebellum, where it plays critical roles in neuronal development, calcium signaling, and synaptic plas |
| Subcellular Localization | the plasma membrane and intracellular membranes, where it responds to neuronal activity and modulates downstream effecto |
| Amino Acids | 295 aa |
| Pathways | MAPK |
| UniProt ID | Q9H0Y9 |
| NCBI Gene ID | 34254 |
| Ensembl ID | ENSG00000154803 |
| OMIM | 607247 |
| GeneCards | RRAS3 |
| Human Protein Atlas | RRAS3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RRAS3["RRAS3"]
neurodegeneration["neurodegeneration"]
RRAS3 -->|"implicated_in"| neurodegeneration
style RRAS3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RRAS3 in their description or question text
No additional research found