protein

RYR1PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RYR1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RyR1 is a massive homotetrameric calcium release channel (~2.2 MDa) located in the endoplasmic/sarcoplasmic reticulum (ER/SR) membrane<sup>[1]</sup>. Each monomer is 5,038 amino acids (~565 kDa), making RyR1 one of the largest known ion channels.

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🔬 Protein Info

Gene Symbol	RYR1PROTEIN
Protein Type	Channel
Function	is a massive homotetrameric calcium release channel (~2.
Primary Expression	Purkinje cells and select brain regions where it participates in intracellular calcium signaling relevant to cerebellar
Subcellular Localization	** \| ER/SR membrane \|
Molecular Weight	565 kDa
Amino Acids	038 aa
GeneCards	RYR1PROTEIN
Human Protein Atlas	RYR1PROTEIN
Transmembrane domain	6 transmembrane helices per subunit forming the ion pore
Selectivity filter	Conserved GGGIG motif determines Ca²⁺ selectivity
Pore helix	Lines the conduction pathway
Luminal domain	Senses ER/SR Ca²⁺ levels
N-terminal domain (NTD)	Contains "hot spots" for disease mutations; involved in channel gating
SPRY domains	Three SPRY domains mediate protein-protein interactions
Associated Diseases	Cardiac
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ryanodine Receptor 1 (RyR1 Protein)

protein · 721 words

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Pathway Diagram

graph TD
    RYR1PROTEIN["RYR1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RYR1PROTEIN -->|"implicated_in"| neurodegeneration
    style RYR1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

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Related Research

Hypotheses and analyses mentioning RYR1PROTEIN in their description or question text

No additional research found