disease

Cardiac

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cardiac: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1156Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Cardiac is a disease characterized by neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Anxiety. Connected to 905 entities in the SciDEX knowledge graph.

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Disease Info

Morphology	cardiac glial cell (source: Cell Ontology)
Atrial ganglia	Located in the walls of the atria, particularly near the sinoatrial and atrioventricular nodes
Ventricular ganglia	Scattered throughout the ventricular myocardium
Coronary sinus region	Around the coronary sinus and pulmonary veins
Associated Genes	GJA1, PDGFRB, LMNA, GENES, STX17, DNA, HCN4, HCN2
KG Connections	1156 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Cardiac Intrinsic Neurons

cell · 1082 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    Cardiac["Cardiac"] -->|"regulates"| Circadian_Rhythm["Circadian Rhythm"]
    Cardiac["Cardiac"] -->|"regulates"| Immune_Response["Immune Response"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Pi3K["Pi3K"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
    Cardiac["Cardiac"] -->|"activates"| Autophagy["Autophagy"]
    HCN1["HCN1"] -->|"regulates"| Cardiac["Cardiac"]
    HCN4["HCN4"] -->|"regulates"| Cardiac["Cardiac"]
    HCN2["HCN2"] -->|"regulates"| Cardiac["Cardiac"]
    BANG["BANG"] -->|"regulates"| Cardiac["Cardiac"]
    style Cardiac fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (295)

Target	Relation	Type	Str
Apoptosis	therapeutic_target	pathway	1.00
Autophagy	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Mitophagy	regulates	pathway	1.00
Sepsis	activates	disease	1.00
Inflammation	activates	disease	1.00
Apoptosis	regulates	pathway	1.00
Mitophagy	activates	pathway	1.00
Ferroptosis	activates	pathway	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Heart Failure	activates	disease	0.95
Atherosclerosis	associated_with	disease	0.95
Apoptosis	inhibits	pathway	0.90
Oxidative Stress	regulates	pathway	0.90
Oxidative Phosphorylation	therapeutic_target	pathway	0.90
Nf-Κb	activates	pathway	0.90
Heart Failure	therapeutic_target	disease	0.85
Heart Failure	regulates	disease	0.85
Immune Response	regulates	pathway	0.80
Ferroptosis	inhibits	pathway	0.80
Mtor	activates	pathway	0.80
Autophagy	inhibits	pathway	0.80
Lipid Metabolism	therapeutic_target	pathway	0.80
Pi3K/Akt	activates	pathway	0.80
Complement	therapeutic_target	pathway	0.80
Differentiation	activates	pathway	0.80
Microrna	therapeutic_target	pathway	0.80
Stem Cell	activates	pathway	0.80
Microrna	regulates	pathway	0.80
Mitochondrial Function	regulates	pathway	0.80
Lipid Metabolism	activates	pathway	0.80
Heart Failure	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Epigenetic	regulates	pathway	0.70
Autophagy	regulates	pathway	0.70
Glycolysis	therapeutic_target	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Lipid Metabolism	regulates	pathway	0.70
Mapk	regulates	pathway	0.70
Oxidative Phosphorylation	regulates	pathway	0.70
Stem Cell	implicated_in	pathway	0.70
Mtor	regulates	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Autophagy	associated_with	pathway	0.70
Pi3K/Akt	implicated_in	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Inflammasome	activates	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Senescence	activates	pathway	0.70

Incoming (861)

Source	Relation	Type	Str
Cardiovascular	associated_with	disease	1.00
NRF2	activates	gene	1.00
SIRT1	activates	gene	1.00
BAX	activates	gene	1.00
BCL-2	activates	gene	1.00
AMPK	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
MITOPHAGY	regulates	gene	1.00
FERROPTOSIS	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Ischemia	activates	disease	1.00
Myocardial Infarction	activates	disease	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
APOPTOSIS	therapeutic_target	gene	1.00
Ischemia	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Als	inhibits	disease	1.00
Fibrosis	activates	disease	1.00
Als	activates	disease	1.00
MITOCHONDRIA	activates	gene	1.00
Cardiovascular	regulates	disease	1.00
Cardiovascular	activates	disease	1.00
Cardiovascular	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
Als	implicated_in	disease	1.00
Cardiovascular	inhibits	disease	1.00
Als	biomarker_for	disease	1.00
Myocardial Infarction	therapeutic_target	disease	1.00
Hypertension	associated_with	disease	0.95
AKT	activates	gene	0.95
NF-ΚB	activates	gene	0.95
MITOPHAGY	activates	gene	0.95
PINK1	regulates	gene	0.95
OXIDATIVE STRESS	regulates	gene	0.95
INFLAMMATION	regulates	gene	0.95
PARKIN	regulates	gene	0.95
CANCER	therapeutic_target	gene	0.95
MIRNAS	regulates	gene	0.95
AGING	activates	gene	0.95
APOPTOSIS	inhibits	gene	0.95
Fibrosis	treats	disease	0.95
ATP	activates	gene	0.95
ROS	regulates	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Cardiac

Understanding Entity Pages

Summary

Wiki Pages (21)

Cardiac Intrinsic Neurons

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

nhp-validation-animal-model

nimodipine-als

Neurons — Cell Type Hierarchy

nct07165106

williams-syndrome

Synucleinopathy Mechanism

Kabuki Syndrome

Vascular Cognitive Impairment (VCI)

Lithium for PSP/CBS — Phase 2 Trial