disease

Cardiac

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cardiac: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1114Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

Cardiac is a disease characterized by neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Anxiety. Connected to 905 entities in the SciDEX knowledge graph.

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Disease Info

Morphology	cardiac glial cell (source: Cell Ontology)
Atrial ganglia	Located in the walls of the atria, particularly near the sinoatrial and atrioventricular nodes
Ventricular ganglia	Scattered throughout the ventricular myocardium
Coronary sinus region	Around the coronary sinus and pulmonary veins
Associated Genes	ACE, AGING, AKT, ALZHEIMER, AND, ANG, APOPTOSIS, AQP4
KG Connections	1114 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Cardiac Intrinsic Neurons

cell · 1082 words

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Validated Hypothesis: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest

hypothesis · 4820 words

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Validated Hypothesis: Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-Amplifying Iron-Ferroptosis-Edema Cascade Post-Cardiac Arrest

hypothesis · 4751 words

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Validated Hypothesis: Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic and Vasogenic Edema After Cardiac Arrest

hypothesis · 4523 words

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PSP Cardiac Autonomic Dysfunction - Deceleration Capacity

mechanism · 1877 words

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Terazosin for Cardiac Autonomic Changes in Early Parkinson's Disease (NCT04386317)

clinical · 1146 words

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Pathway Diagram

graph TD
    Cardiac["Cardiac"] -->|"regulates"| Circadian_Rhythm["Circadian Rhythm"]
    Cardiac["Cardiac"] -->|"regulates"| Immune_Response["Immune Response"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Pi3K["Pi3K"]
    Cardiac["Cardiac"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
    Cardiac["Cardiac"] -->|"activates"| Autophagy["Autophagy"]
    HCN1["HCN1"] -->|"regulates"| Cardiac["Cardiac"]
    HCN4["HCN4"] -->|"regulates"| Cardiac["Cardiac"]
    HCN2["HCN2"] -->|"regulates"| Cardiac["Cardiac"]
    BANG["BANG"] -->|"regulates"| Cardiac["Cardiac"]
    style Cardiac fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (284)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Inflammation	activates	disease	1.00
Apoptosis	regulates	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Sepsis	activates	disease	1.00
Autophagy	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Mitophagy	activates	pathway	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Ferroptosis	activates	pathway	1.00
Atherosclerosis	associated_with	disease	0.95
Heart Failure	activates	disease	0.95
Oxidative Phosphorylation	therapeutic_target	pathway	0.90
Oxidative Stress	regulates	pathway	0.90
Apoptosis	inhibits	pathway	0.90
Nf-Κb	activates	pathway	0.90
Heart Failure	therapeutic_target	disease	0.85
Heart Failure	regulates	disease	0.85
Ferroptosis	inhibits	pathway	0.80
Mtor	activates	pathway	0.80
Lipid Metabolism	therapeutic_target	pathway	0.80
Autophagy	inhibits	pathway	0.80
Lipid Metabolism	activates	pathway	0.80
Pi3K/Akt	activates	pathway	0.80
Differentiation	activates	pathway	0.80
Microrna	therapeutic_target	pathway	0.80
Mitochondrial Function	regulates	pathway	0.80
Complement	therapeutic_target	pathway	0.80
Stem Cell	activates	pathway	0.80
Immune Response	regulates	pathway	0.80
Microrna	regulates	pathway	0.80
Heart Failure	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Inflammasome	activates	pathway	0.70
Cholesterol	regulates	pathway	0.70
Mitophagy	inhibits	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Glycolysis	activates	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Pi3K/Akt	implicated_in	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Oxidative Stress	inhibits	pathway	0.70
Angiogenesis	activates	pathway	0.70
Angiogenesis	therapeutic_target	pathway	0.70
Complement	inhibits	pathway	0.70
Mitochondrial Function	treats	pathway	0.70
Senescence	activates	pathway	0.70
Mitophagy	associated_with	pathway	0.70
Mapk	activates	pathway	0.70

Incoming (830)

Source	Relation	Type	Str
Als	inhibits	disease	1.00
NRF2	activates	gene	1.00
Myocardial Infarction	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Cardiovascular	therapeutic_target	disease	1.00
Fibrosis	activates	disease	1.00
AUTOPHAGY	activates	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
Myocardial Infarction	activates	disease	1.00
SIRT1	activates	gene	1.00
Ischemia	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
BAX	activates	gene	1.00
Als	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
MITOPHAGY	regulates	gene	1.00
Als	biomarker_for	disease	1.00
MITOCHONDRIA	activates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
Ischemia	therapeutic_target	disease	1.00
BCL-2	activates	gene	1.00
Als	associated_with	disease	1.00
AMPK	activates	gene	1.00
Cardiovascular	activates	disease	1.00
Cardiovascular	regulates	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
Als	regulates	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Cardiovascular	inhibits	disease	1.00
FERROPTOSIS	activates	gene	1.00
Cardiovascular	associated_with	disease	1.00
APOPTOSIS	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	1.00
GENES	regulates	gene	0.95
CANCER	therapeutic_target	gene	0.95
INFLAMMATION	regulates	gene	0.95
MIRNAS	regulates	gene	0.95
ROS	regulates	gene	0.95
Fibrosis	treats	disease	0.95
OXIDATIVE STRESS	regulates	gene	0.95
Hypertension	associated_with	disease	0.95
APOPTOSIS	inhibits	gene	0.95
ATP	activates	gene	0.95
PINK1	regulates	gene	0.95
PARKIN	regulates	gene	0.95
NF-ΚB	activates	gene	0.95
AGING	activates	gene	0.95
Heart Failure	therapeutic_target	disease	0.95

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Cardiac-Inspired Neuroprotective TREM2hi Strategy	0.000	-	TREM2 Therapeutic Strategy Post-INVOKE-2

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 12 hypotheses Top: 0.838

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat	in_vivo	post-cardiac-arrest neurodegen	0.768	0.72	Sprague-Dawley rat asphyxial c	abandoned	$48,000

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085]	Wen H, Zi Y, Liu Z, Bai Y, Lin J et al.	Cell Death Differ	2026
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462]	Tan Y, Ye H, Ge Q, Wang P, Liu Z et al.	J Magn Reson Imaging	2026
Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axon [PMID:41967652]	Fang J, Pan X, Chen J	Neurobiol Dis	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
The cornel Iridoid glycoside attenuated brain edema of the cerebral ischemia/rep [PMID:38950636]	Wang Z, Xue F, Zhang J	Fitoterapia	2024
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Goreisan Prevents Brain Edema after Cerebral Ischemic Stroke by Inhibiting Aquap [PMID:29153303]	Nakano T, Nishigami C, Irie K	J Stroke Cerebrovasc Dis	2018
Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquapor [PMID:30093197]	Cheng ZJ, Dai TM, Shen YY	J Stroke Cerebrovasc Dis	2018
Curcumin attenuates brain edema in mice with intracerebral hemorrhage through in [PMID:26119880]	Wang BF, Cui ZW, Zhong ZH	Acta Pharmacol Sin	2015

Debates (1)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

Related Research

Hypotheses and analyses mentioning Cardiac in their description or question text

No additional research found

Cardiac

Understanding Entity Pages

Summary

Wiki Pages (10)

Cardiac Intrinsic Neurons

Validated Hypothesis: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis After Cardiac Arrest

Validated Hypothesis: Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-Amplifying Iron-Ferroptosis-Edema Cascade Post-Cardiac Arrest

Validated Hypothesis: Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic and Vasogenic Edema After Cardiac Arrest

PSP Cardiac Autonomic Dysfunction - Deceleration Capacity

Terazosin for Cardiac Autonomic Changes in Early Parkinson's Disease (NCT04386317)

Nucleus Ambiguus in Cardiac Control

Cardiac MIBG Scan for Parkinsonism

Vitamin D3 Cardiac Autonomic PD Trial (NCT07084597)

Intrinsic Cardiac Neurons

Pathway Diagram

Outgoing (284)

Incoming (830)

Targeting Hypotheses (4)

Mentioning Analyses (1)

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

Experiments (1)

Related Papers (12)

Debates (1)

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

Related Research