| Gene Symbol | RYR1PROTEIN |
| Protein Type | Channel |
| Function | is a massive homotetrameric calcium release channel (~2. |
| Primary Expression | Purkinje cells and select brain regions where it participates in intracellular calcium signaling relevant to cerebellar |
| Subcellular Localization | ** | ER/SR membrane | |
| Molecular Weight | 565 kDa |
| Amino Acids | 038 aa |
| GeneCards | RYR1PROTEIN |
| Human Protein Atlas | RYR1PROTEIN |
| Transmembrane domain | 6 transmembrane helices per subunit forming the ion pore |
| Selectivity filter | Conserved GGGIG motif determines Ca²⁺ selectivity |
| Pore helix | Lines the conduction pathway |
| Luminal domain | Senses ER/SR Ca²⁺ levels |
| N-terminal domain (NTD) | Contains "hot spots" for disease mutations; involved in channel gating |
| SPRY domains | Three SPRY domains mediate protein-protein interactions |
| Associated Diseases | Cardiac |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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