protein

RYR3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RYR3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RyR3 is the third isoform of the ryanodine receptor family, forming a homotetrameric ER calcium release channel of similar size to RyR1 and RyR2<sup>[1]</sup>. Each subunit is 4,872 amino acids.

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🔬 Protein Info

Gene Symbol	RYR3PROTEIN
Protein Type	Channel
Function	is an intracellular calcium release channel expressed in brain, smooth muscle, and diaphragm.
Primary Expression	brain, smooth muscle, and diaphragm
Subcellular Localization	** \| ER membrane \|
Molecular Weight	552 kDa
Amino Acids	872 aa
GeneCards	RYR3PROTEIN
Human Protein Atlas	RYR3PROTEIN
Hippocampal CA1	Enriched in dendritic spines where it modulates calcium signals underlying LTP/LTD
Striatal [neurons](/entities/neurons)	Contributes to dopamine-mediated calcium signaling
Thalamic relay neurons	Participates in oscillatory calcium activity
Neonatal brain	Highly expressed during brain development, suggesting developmental roles
Lower Ca²⁺ sensitivity	Higher threshold for calcium-induced calcium release
No inactivation at high Ca²⁺	Unlike RyR1, RyR3 does not inactivate at micromolar Ca²⁺
Associated Diseases	Cardiac
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ryanodine Receptor 3 (RyR3 Protein)

protein · 575 words

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Pathway Diagram

graph TD
    RYR3PROTEIN["RYR3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RYR3PROTEIN -->|"implicated_in"| neurodegeneration
    style RYR3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

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