| Gene Symbol | RYR3PROTEIN |
| Protein Type | Channel |
| Function | is an intracellular calcium release channel expressed in brain, smooth muscle, and diaphragm. |
| Primary Expression | brain, smooth muscle, and diaphragm |
| Subcellular Localization | ** | ER membrane | |
| Molecular Weight | 552 kDa |
| Amino Acids | 872 aa |
| GeneCards | RYR3PROTEIN |
| Human Protein Atlas | RYR3PROTEIN |
| Hippocampal CA1 | Enriched in dendritic spines where it modulates calcium signals underlying LTP/LTD |
| Striatal [neurons](/entities/neurons) | Contributes to dopamine-mediated calcium signaling |
| Thalamic relay neurons | Participates in oscillatory calcium activity |
| Neonatal brain | Highly expressed during brain development, suggesting developmental roles |
| Lower Ca²⁺ sensitivity | Higher threshold for calcium-induced calcium release |
| No inactivation at high Ca²⁺ | Unlike RyR1, RyR3 does not inactivate at micromolar Ca²⁺ |
| Associated Diseases | Cardiac |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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