gene

SAR1A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SAR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: SAR1A - Secretion Associated Ras Related GTPase 1A involved in COPII vesicle formation, ER-to-Golgi trafficking, protein quality control, and neurodegeneration

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🧬 Gene Info

Gene Symbol	SAR1A
Full Name	Secretion Associated Ras Related GTPase 1A
Aliases	Gene profile: SAR1A
Chromosome	10q21.3
Protein Family	Arf/Sar GTPase family
Function	is a small GTPase belonging to the Arf/Sar family that plays a critical role in COPII (Coat Protein Complex II) vesicle formation at the endoplasmic reticulum (ER).
Amino Acids	198 aa
Exons	5
UniProt ID	[Q9Y5B1](https://www.uniprot.org/uniprot/Q9Y5B1)
Ensembl ID	ENSG00000094841
GeneCards	SAR1A
Human Protein Atlas	SAR1A
SAR1A	The major isoform in most tissues
SAR1B	Closely related paralog with overlapping function
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SAR1A Gene

gene · 1648 words

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Pathway Diagram

graph TD
    SAR1A["SAR1A"]
    neurodegeneration["neurodegeneration"]
    SAR1A -->|"implicated_in"| neurodegeneration
    style SAR1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SAR1A in their description or question text

No additional research found