Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN10A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Sodium Voltage-Gated Channel Alpha Subunit 10 (Nav1.8) - pain-sensing sodium channel implicated in small fiber neuropathy, cardiac arrhythmias, and neurodegeneration
| Gene Symbol | SCN10A |
| Full Name | Sodium Voltage-Gated Channel Alpha Subunit 10 |
| Aliases | Nav1.8 |
| Chromosome | 3p21-p22 |
| Protein Type | Channel |
| Function | is a member of the Nav1 family of voltage-gated sodium channels (Na<sub>v</sub>1. |
| Primary Expression | Peripheral sensory neurons, cardiac conduction system, sympathetic neurons |
| Molecular Weight | ~220 kDa |
| Amino Acids | 2016 aa |
| Exons | 26 coding exons |
| UniProt ID | Q9Y5Y9 |
| NCBI Gene ID | 6336 |
| Ensembl ID | ENSG00000185313 |
| OMIM | 613217 |
| GeneCards | SCN10A |
| Human Protein Atlas | SCN10A |
| Associated Diseases | ALS |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SCN10A["SCN10A"]
SCN10A -->|"causes"| Als["Als"]
SCN10A -->|"causes"| ALS["ALS"]
SCN10A -->|"causes"| AND["AND"]
SCN10A -->|"causes"| App["App"]
SCN10A -->|"implicated in"| neurodegeneration["neurodegeneration"]
SCN10A ---|"associated"| INPP4A["INPP4A"]
SCN10A ---|"associated"| XPR1["XPR1"]
SCN10A ---|"associated"| P2RX7["P2RX7"]
SCN10A ---|"associated"| CAMSAP1["CAMSAP1"]
SCN10A ---|"associated"| Genes["Genes"]
P2RX7 ---|"associated"| SCN10A
XPR1 ---|"associated"| SCN10A
GENES["GENES"] ---|"associated"| SCN10A
INPP4A ---|"associated"| SCN10AHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||