Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SCN9A |
| Aliases | Nav1.7 |
| Function | Nav1.7 channels are voltage-gated sodium channels that mediate the rapid depolarization phase of action potentials in excitable cells. |
| Primary Expression | Highly expressed in peripheral sensory neurons (dorsal root ganglia, trigeminal ganglia), olfactory epithelium, and sympathetic neurons |
| Ensembl ID | ENSG00000169432 |
| GeneCards | SCN9A |
| Human Protein Atlas | SCN9A |
| Associated Diseases | neurodegeneration |
| Interactions | NRF2 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SCN9A(["SCN9A"])
style SCN9A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
neurons["/"neurons"/"]
neurodegeneration["neurodegeneration"]
SCN9A -->|"expressed_in"| neurons
SCN9A -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class neurons mechanism
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| Nociceptive Transmission | promotes | process | 0.91 |
| Endocytosis | involved_in | process | 0.88 |
| neurons | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||