pathway

Endocytosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Endocytosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

687Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Endocytosis is a biological pathway involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Aging, Als. Connected to 353 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Endocytosis
Key Genes/Proteins	Designed Endocytosis-Inducing Proteins, TFEB, FLOT1, MTORC1, Extracellular α-Synuclein Fibrils
Related Diseases	Cancer
Related Pathways	MTORC1 Signaling, Signal Amplification

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Endocytosis["Endocytosis"] -->|"interacts"| Complement["Complement"]
    Endocytosis["Endocytosis"] -->|"interacts"| Exocytosis["Exocytosis"]
    Endocytosis["Endocytosis"] -->|"interacts"| Angiogenesis["Angiogenesis"]
    Endocytosis["Endocytosis"] -->|"interacts"| Apoptosis["Apoptosis"]
    Endocytosis["Endocytosis"] -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    Endocytosis["Endocytosis"] -->|"interacts"| Autophagy["Autophagy"]
    TARDBP["TARDBP"] -->|"expressed in"| Endocytosis["Endocytosis"]
    NTN1["NTN1"] -->|"expressed in"| Endocytosis["Endocytosis"]
    SNRNP70["SNRNP70"] -->|"expressed in"| Endocytosis["Endocytosis"]
    JUN["JUN"] -->|"expressed in"| Endocytosis["Endocytosis"]
    style Endocytosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (71)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Lysosomes	involved_in	cell_type	0.95
MTORC1 Signaling	mediates	pathway	0.90
MTORC1	activates	protein	0.90
Target Degradation	mediates	process	0.90
Signal Amplification	contributes_to	mechanism	0.90
Protein Degradation	contributes_to	process	0.85
Alzheimer Disease	associated_with	disease	0.85
Alzheimer's Disease	associated_with	disease	0.85
Signal Amplification	mediates	process	0.85
Tau Pathology Propagation	mediates	process	0.85
Casm	activates	process	0.80
Protein Degradation	promotes	process	0.80
Complement	interacts_with	pathway	0.55
Exocytosis	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Exocytosis	regulates	pathway	0.50
Proteins	regulates	protein	0.50
Proteins	activates	protein	0.50
Proteins	interacts_with	protein	0.50
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
Exocytosis	associated_with	pathway	0.50
SYNAPSE	interacts_with	concept	0.50
MTOR SIGNALING	interacts_with	concept	0.50
ENDOSOMES	activates	concept	0.50
Infection	activates	disease	0.50
LYSOSOME	associated_with	gene	0.50
DOPAMINE	regulates	concept	0.50
BERBERINE	regulates	concept	0.50
Endothelial Cell	regulates	cell_type	0.50
ENDOTHELIAL	regulates	concept	0.50
ISCHEMIC	regulates	concept	0.50
ISCHEMIC STROKE	regulates	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
Endothelial Cell	interacts_with	cell_type	0.50
ENDOTHELIAL	interacts_with	concept	0.50
ENDOTHELIAL CELLS	interacts_with	concept	0.50
STEM CELLS	interacts_with	concept	0.50
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
TAU PATHOLOGY	interacts_with	concept	0.50
ENDOSOME	interacts_with	concept	0.50

Incoming (616)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
Cancer	therapeutic_target	disease	1.00
Designed Endocytosis-Inducing Proteins	activates	protein	0.95
TFEB	upregulates	gene	0.95
Lysosomes	involved_in	cell_type	0.95
Designed Endocytosis-Inducing Proteins	associated_with	protein	0.95
FLOT1	involved_in	protein	0.95
Extracellular α-Synuclein Fibrils	involved_in	protein	0.90
Extracellular Α-Synuclein Fibrils	involved_in	compound	0.90
Designed Endocytosis-Inducing Proteins	involved_in	protein	0.90
CANCER	therapeutic_target	gene	0.90
SCN9A	involved_in	gene	0.88
EPSIN1	involved_in	protein	0.85
EPSIN2	involved_in	protein	0.85
Dopamine D3 Receptor	mediates	receptor	0.85
Annexins	involved_in	protein	0.85
SNCA	involved_in	protein	0.85
BIN1 Loss	upregulates	mechanism	0.85
BIN1	involved_in	protein	0.85
ANNEXINS	involved_in	protein	0.80
Alzheimer	therapeutic_target	disease	0.80
Tumor	therapeutic_target	disease	0.80
AUTOPHAGY	associated_with	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
Als	therapeutic_target	disease	0.80
EGF	activates	gene	0.70
Als	regulates	disease	0.70
Als	activates	disease	0.70
Alzheimer	associated_with	disease	0.70
Neurodegeneration	associated_with	disease	0.70
LC3	associated_with	gene	0.70
Als	inhibits	disease	0.70
PHAGOCYTOSIS	associated_with	gene	0.70
APOPTOSIS	regulates	gene	0.70
CANCER	activates	gene	0.70
TAU	inhibits	gene	0.70
COMPLEMENT	regulates	gene	0.70
CANCER	regulates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
LYSOSOME	activates	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
ALZHEIMER	associated_with	gene	0.70
AMYLOID	interacts_with	gene	0.70
DNA	therapeutic_target	gene	0.70
ROS	therapeutic_target	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
Alzheimer	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Endocytosis

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Alpha-Synuclein Pathology

GRIA3 Gene

Alzheimer's Disease

Astrocyte Reactivity Mechanism

Mitochondrial Dysfunction in Parkinson's Disease

CLCN10 — Chloride Voltage-Gated Channel 10

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Tau Spreading Mechanism

APOC4 — Apolipoprotein C-IV

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

gabaergic-dysfunction

TREM2 Microglial Signaling Pathway in Neurodegeneration

dendritic-spines

Synaptic Vesicle Trafficking in Parkinson's Disease

psp-tauopathy

Niemann-Pick Disease Type C (NPC)