cell_type

neurons

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4733Connections

17Hypotheses

30Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	neurons
Definition	<table class="infobox infobox-therapeutic">
Key Markers	CX3CL1, CD38, STING, ALS, BDNF, DNA, RNA, ROS
Key Pathways	mitochondrial dynamics, ferroptosis, necroptosis, cGAS-STING, BDNF-TrkB signaling
Associated Diseases	Neurodegenerative Diseases, Premature Senescence, neurodegeneration, Alzheimer's disease, neuroinflammation, ALS
Linked Hypotheses	250 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    neurons["neurons"] -->|"regulates"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurons["neurons"] -->|"activates"| Alzheimer_s_disease["Alzheimer's disease"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurons["neurons"] -->|"activates"| neuroinflammation["neuroinflammation"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurons["neurons"] -->|"associated"| ALS["ALS"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurons["neurons"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurons["neurons"] -->|"activates"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    neurons["neurons"] -->|"activates"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    neurodegeneration_1["neurodegeneration"] -->|"affects"| neurons["neurons"]
    style neurodegeneration_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"active in"| neurons["neurons"]
    style synaptic_plasticity fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    epilepsy["epilepsy"] -->|"affects"| neurons["neurons"]
    style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neuroinflammation_2["neuroinflammation"] -->|"affects"| neurons["neurons"]
    style neuroinflammation_2 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    anxiety["anxiety"] -->|"affects"| neurons["neurons"]
    style anxiety fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style neurons fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1101)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
neurodegeneration	regulates	disease	0.90
neurodegeneration	activates	disease	0.90
Alzheimer's disease	activates	disease	0.90
neuroinflammation	activates	disease	0.90
neurodegeneration	associated_with	disease	0.90
ALS	associated_with	disease	0.90
neurodegeneration	causes	disease	0.90
ALS	causes	disease	0.90
Alzheimer's disease	associated_with	disease	0.90
neurodegeneration	expressed_in	disease	0.90
ALS	implicated_in	disease	0.90
autophagy pathway	active_in	pathway	0.85
pyroptosis	active_in	pathway	0.85
synaptic plasticity	active_in	pathway	0.85
oxidative stress response	active_in	pathway	0.85
cholesterol homeostasis	active_in	pathway	0.85
glutamate signaling	active_in	pathway	0.85
neurotrophin signaling	active_in	pathway	0.85
mitochondrial function	active_in	pathway	0.85
unfolded protein response	active_in	pathway	0.85
NAD+ metabolism	active_in	pathway	0.85
circadian regulation	active_in	pathway	0.85
epigenetic regulation	active_in	pathway	0.85
insulin signaling	active_in	pathway	0.85
brain-derived extracellular vesicles	mediates	compound	0.85
Parkinson's disease	associated_with	disease	0.80
ALS	activates	disease	0.80
neuroinflammation	regulates	disease	0.80
pyroptosis	activates	process	0.80
ferroptosis	activates	process	0.80
Alzheimer's disease	interacts_with	disease	0.80
neurodegeneration	inhibits	disease	0.80
Alzheimer's disease	implicated_in	disease	0.80
neurodegeneration	interacts_with	disease	0.80
tau phosphorylation	activates	process	0.80
NF-kB signaling	active_in	pathway	0.75
purinergic signaling	active_in	pathway	0.75
senescence	active_in	pathway	0.75
MAPK signaling	active_in	pathway	0.75
sphingolipid metabolism	active_in	pathway	0.75
ubiquitin-proteasome	active_in	pathway	0.75
calcium signaling	active_in	pathway	0.75
Parkinson's disease	expressed_in	disease	0.70
Parkinson's disease	regulates	disease	0.70
Alzheimer's disease	causes	disease	0.70
neuroinflammation	expressed_in	disease	0.70
Alzheimer's disease	inhibits	disease	0.70
Parkinson's disease	implicated_in	disease	0.70
neuroinflammation	implicated_in	disease	0.70

Incoming (3632)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
opsin	activates	protein	0.95
neurodegeneration	affects	disease	0.90
synaptic plasticity	active_in	pathway	0.90
epilepsy	affects	disease	0.90
neuroinflammation	affects	disease	0.90
anxiety	affects	disease	0.90
NF-kB signaling	active_in	pathway	0.90
STING	activates	gene	0.90
unfolded protein response	active_in	pathway	0.90
ALS	protects_against	gene	0.90
ALS	affects	disease	0.90
aging	affects	disease	0.90
Parkinson's disease	affects	disease	0.90
BDNF	activates	gene	0.90
ALS	regulates	gene	0.90
autophagy pathway	active_in	pathway	0.90
ALS	causes	gene	0.90
ALS	activates	gene	0.90
DNA	activates	gene	0.90
frontotemporal dementia	affects	disease	0.90
DNA	interacts_with	gene	0.90
RNA	activates	gene	0.90
Alzheimer's disease	affects	disease	0.90
RNA	expressed_in	gene	0.90
depression	affects	disease	0.90
RNA	associated_with	gene	0.90
mitochondrial dynamics	active_in	pathway	0.90
multiple sclerosis	affects	disease	0.90
ALS	associated_with	gene	0.90
RNA	regulates	gene	0.90
prion disease	affects	disease	0.90
Huntington's disease	affects	disease	0.90
traumatic brain injury	affects	disease	0.90
stroke	affects	disease	0.90
C3	activates	gene	0.90
BDNF	associated_with	gene	0.90
ALS	expressed_in	gene	0.90
ALS	implicated_in	gene	0.90
ALS	treats	gene	0.90
DNA	associated_with	gene	0.90
pyroptosis	active_in	pathway	0.90
ferroptosis	active_in	pathway	0.90
STING	associated_with	gene	0.90
glutamate signaling	active_in	pathway	0.90
TNF	activates	gene	0.90
ROS	activates	gene	0.90
AMPK	activates	gene	0.90
ALS	inhibits	gene	0.90
diabetes	affects	disease	0.90

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.559	neurodegeneration	How does PIKFYVE inhibition activate unc
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Layer V excitatory neurons show selectively enhanced vulnera	0.510	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu	0.470	neurodegeneration	Gene expression changes in aging mouse b
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.505

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361]	Han SC, Han J, Min YK, Han JW, Jeong HJ	Am J Sports Med	2026
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967]	Huang X, Francis I, Gu Y, Saha SC	Respir Physiol Neurobiol	2026
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313]	Samante FI, Galangue CG, Avelino DC, Bel	Pharmacol Rep	2026
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213]	Wu J, Lin B, Yang S, Xu S, Li S	J Prosthet Dent	2026
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135]	Walsh RM, Crabtree GW, Kalpana K, Jubier	bioRxiv	2024
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024

neurons

Understanding Entity Pages

Wiki Pages (21)

Neurons in Dentatorubral-Pallidoluysian Atrophy

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Pathway Diagram

Outgoing (1101)

Incoming (3632)

Targeting Hypotheses (17)

Mentioning Analyses (30)

What are the precise temporal dynamics of astrocyte ketone production decline du

Why does autophagy inhibition improve neuronal survival when autophagy is typica

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

What are the molecular determinants that control directional mitochondrial trans

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Do stellate neurons express unique α7 nicotinic receptor subtypes that could ena

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons

Investigate mechanisms of epigenetic reprogramming in aging neurons

How do protein-protein interactions determine subcellular localization and funct

What mechanisms underlie neuronal resistance to autophagy induction compared to

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Investigate mechanisms of epigenetic reprogramming in aging neurons

Epigenetic reprogramming in aging neurons

epigenetic reprogramming aging neurons

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Entorhinal cortex layer II vulnerability in Alzheimer's disease

Epigenetic reprogramming in aging neurons

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Extracellular vesicle biomarkers for early AD detection

Related Papers (20)