Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SELECTIVE_AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SQSTM1 | mediates | gene | 0.90 |
| ULK1 | regulates | protein | 0.72 |
| SQSTM1 | regulates | gene | 0.70 |
| TFEB-TFE3 heterodimers | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| J-protein co-chaperone system mediates selective autophagy t | 0.831 | protein-biochemistry | Do chaperones selectively recognize path |
| TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, a | 0.776 | multi | Cross-disease neurodegeneration mechanis |
| CHIP-mediated K63-linked ubiquitination redirects oligomeric | 0.380 | protein-biochemistry | Do chaperones selectively recognize path |
| Chaperone-Autophagy Coupling Prevents Aggregate Persistence | 0.380 | protein-folding | Can chaperone enhancement approaches ove |
| Chaperone-Autophagy Coupling Prevents Aggregate Persistence | 0.380 | protein-folding | Can chaperone enhancement approaches ove |
| Synaptic-Selective Autophagy Receptor Expression to Bypass A | 0.370 | proteomics | Quantitative proteomics of the aging syn |
| Pharmacological Chaperone-Mediated Selective Autophagy | 0.000 | - | GBA-Synuclein Loop Therapeutics for PD |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.697
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089] | Quinn PMJ, Moreira PI, Ambrósio AF, Alve | Acta neuropathologica communic | 2020 | 0 |
| Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. [PMID:25803835] | Unknown | Nature neuroscience | 2015 | 0 |
| The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. [PMID:25611507] | ["Pickrell Alicia M", "Youle Richard J"] | Neuron | 2015 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.94 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning SELECTIVE_AUTOPHAGY in their description or question text
Score: 0.370 · proteomics · 2026-04-25
Synaptic-Selective Autophagy Receptor Expression to Bypass Axonal Lysosome Deficiency
Score: 0.000 · unknown disease · 2026-04-28
Engineering selective autophagy receptors using ambroxol derivatives conjugated to AUTACs for targeted degradation of pa