gene

ULK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ULK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2349Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

ULK1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALI, ALS. Connected to 1157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ULK1
Full Name	UNC-51 Like Kinase 1
Chromosome	2q24
Protein Family	Ser/Thr kinase (ULK family)
Protein Type	Kinase
Target Class	Kinase
Function	ULK1 is the initiating kinase for autophagy
Mechanism of Action	Small molecule activators or inhibitors of ULK1 kinase activity to modulate autophagy
Subcellular Localization	Cytoplasm, autophagosome
Druggability	Low (0.42)
Clinical Stage	Phase I
Molecular Weight	~1,050 amino acids (~112 kDa)
Amino Acids	050 aa
Pathways	AUTOPHAGY, Autophagy, Cell Cycle, Chaperone, Differentiation
UniProt ID	Q8N448
GeneCards	ULK1
Human Protein Atlas	ULK1
Associated Diseases	AD, ALI, ALS, ALZHEIMER, AMI, ARM
Known Drugs/Compounds	RAPAMYCIN, Shikonin, echinacoside, statins, ALT001, rapamycin
Interactions	CLOCK, ATG5, EIF4EBP1, LC3, MTOR, ABCG1
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	TFEB-Independent Autophagy Bypass
KG Connections	2349 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: ULK1 — PDB 4WNO Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ULK1["ULK1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    ULK1["ULK1"] -->|"interacts"| CLOCK["CLOCK"]
    ULK1["ULK1"] -->|"co discussed"| PDGFRB["PDGFRB"]
    ULK1["ULK1"] -->|"co discussed"| TGFB1["TGFB1"]
    CLOCK_1["CLOCK"] -->|"interacts"| ULK1["ULK1"]
    BMAL1["BMAL1"] -->|"co discussed"| ULK1["ULK1"]
    CLOCK_2["CLOCK"] -->|"co discussed"| ULK1["ULK1"]
    CRH["CRH"] -->|"co discussed"| ULK1["ULK1"]
    style ULK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1125)

Target	Relation	Type	Str
MTOR	activates	gene	1.00
AUTOPHAGY	regulates	pathway	1.00
Autophagy	interacts_with	pathway	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	1.00
Mtor	activates	pathway	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Selective Autophagy	involved_in	process	0.95
Autophagosome Biogenesis	involved_in	process	0.95
autophagy initiation	regulates	process	0.95
Als	interacts_with	disease	0.95
Inflammation	activates	disease	0.95
Cancer	inhibits	disease	0.95
APG115	synthetic_lethal_with	drug	0.93
frontotemporal lobar degeneration	biomarker_for	disease	0.92
pyroptosis	inhibits	process	0.92
autophagy	activates	pathway	0.90
SQSTM1	phosphorylates	protein	0.90
phagophore formation	activates	pathway	0.90
autophagy	regulates	process	0.90
ferritinophagy	activates	pathway	0.90
Macroautophagy	activates	process	0.90
Autophagosome Biogenesis	mediates	process	0.90
BECN1	phosphorylates	protein	0.90
Autophagy Initiation	involved_in	process	0.90
programmed mitophagy	regulates	process	0.90
NIX-dependent mitophagy	regulates	process	0.90
damaged mitochondria accumulation	promotes	phenotype	0.90
autophagy activation	activates	process	0.90
AMPK signaling	participates_in	pathway	0.90
Mitophagy	regulates	process	0.90
VPS34	activates	protein	0.90
Alzheimer's disease	biomarker_for	disease	0.90
microglia	expressed_in	cell_type	0.90
oxidative stress response	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
Autophagy	associated_with	pathway	0.90
Autophagy	therapeutic_target	pathway	0.90
Mitophagy	activates	pathway	0.90
diabetic kidney disease	protective_against	disease	0.88
kidney injury	prevents	phenotype	0.88
Mitochondrial Homeostasis	associated_with	process	0.85
Mitochondrial Autophagy	regulates	process	0.85
NIX-Dependent Mitophagy	involved_in	process	0.85
cellular homeostasis	maintains	process	0.85
autophagy initiation	upstream_of	process	0.85
Tumor	associated_with	disease	0.85
Cancer	therapeutic_target	disease	0.85
Als	regulates	disease	0.85

Incoming (1224)

Source	Relation	Type	Str
LC3	activates	gene	1.00
AMPK	activates	protein	1.00
AMPK	regulates	protein	1.00
MITOCHONDRIA	activates	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
TRIM49	interacts_with	gene	0.95
SESTRIN2	interacts_with	protein	0.95
RAPAMYCIN	activates	drug	0.95
SESTRIN2	modulates	protein	0.92
mTORC1	inhibits	protein	0.90
mTORC1	regulates	protein	0.90
STAT1	associated_with	protein	0.90
Acetylation	modulates	process	0.90
TRIM49	regulates	gene	0.90
AMPK	upstream_of	protein	0.90
MAP1LC3	activates	gene	0.90
MAP1LC3	regulates	gene	0.90
ATG	regulates	gene	0.90
rapamycin	targets	drug	0.90
h-0e0cc0c1	targets_gene	hypothesis	0.90
h-1e4bba56	targets_gene	hypothesis	0.90
ATG5	activates	gene	0.90
LC3	interacts_with	gene	0.90
LC3	regulates	gene	0.90
MITOPHAGY	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
SMCR8	regulates	entity	0.88
SQSTM1	phosphorylates	gene	0.85
Energy Deprivation	activates	process	0.85
STAT1	downregulates	protein	0.85
14-3-3	binds_to	protein	0.85
TBK1	phosphorylates	protein	0.85
Shikonin	activates	drug	0.85
exercise	activates	phenotype	0.85
PP2Ac	phosphorylates	protein	0.85
XIAP	phosphorylates	protein	0.85
echinacoside	activates	drug	0.85
FIP200	interacts_with	protein	0.84
TBK1	activates	protein	0.82
MTOR	regulates	protein	0.80
MLKL	regulates	gene	0.80
ubiquitin	modifies	protein	0.80
h-0e0cc0c1	targets	hypothesis	0.80
NDP52	regulates	gene	0.80
LAMP2	regulates	gene	0.80
STX17	co_mentioned_with	gene	0.80
ALT001	activates	drug	0.80
ATG	component_of	gene	0.80
mTOR	phosphorylates	pathway	0.80
AUTOPHAGY	participates_in	pathway	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TFEB-Independent Autophagy Bypass	0.510	neurodegeneration	Does TFEB dysfunction cause neurodegener

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung [PMID:40702660]	Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T	Autophagy	2026
Nanocarrier-enhanced simvastatin modulates AMPK-ULK1 pathway and oxidative stres [PMID:41314452]	Afify AM, El-Sayed EK, Ismail A, Nofal S	Eur J Pharmacol	2026
Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under imm [PMID:41380676]	Wu MM, Yang YC, Hu ZQ, Chang JY, Xiao H	Cell Metab	2026
AMPK promotes TFEB transcriptional activity through dephosphorylation at both MT [PMID:41661247]	Negoita F, Fraguas Bringas C, Hellberg K	Autophagy	2026
Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy [PMID:41672028]	Ye J, Wang D, Pang H, Liu Q, Pan Z et al	Eur J Med Chem	2026
Neuronal PPP2R5C in plasma is a potential biomarker for early diagnosis of Alzhe [PMID:41720088]	Luo S, Liu H, Xiao T, Li Y, Liu X et al.	Cell Rep Med	2026
Prussian Blue Nanozyme Disrupts the Self-Reinforcing Loop of Tauopathy via Tripl [PMID:41797478]	Wu F, Huang J, Wang J, Wu R, Zhang H et	Adv Healthc Mater	2026
SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer [PMID:41811103]	Chen Y, Ji X, Zhao J, Bao Z, Huang Y	CNS Neurosci Ther	2026
The Human Autophagy Core Complexes. [PMID:41880641]	Hurley JH	Annu Rev Biochem	2026
Exercise-Induced Exerkines Modulate Autophagy: Implications for Interorgan Cross [PMID:41898620]	Deng Q, Huang J, Wang C, Liang J	Int J Mol Sci	2026
The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via [PMID:41572497]	Cao SQ, Jiménez-Loygorri JI, Qiu Y, Kang	Advanced science (Weinheim, Ba	2026

ULK1

Understanding Entity Pages

Summary

Wiki Pages (21)

ULK1 — UNC-51 Like Kinase 1

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Novel Therapy Index

Mitochondrial Quality Control

Autophagy Mechanisms

Pathway Diagram

Outgoing (1125)

Incoming (1224)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

Digital biomarkers and AI-driven early detection of neurodegeneration

Mechanistic role of APOE in neurodegeneration

Related Papers (11)

ULK1

Understanding Entity Pages

Summary

Wiki Pages (21)

ULK1 — UNC-51 Like Kinase 1

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Novel Therapy Index

Mitochondrial Quality Control

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Copper Dyshomeostasis in Neurodegeneration

Gene-Mechanism-Therapy Causal Chains

Insulin Signaling in Parkinson's Disease

proteasome-ubiquitin-system-dysfunction-parkinsons

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

FOXO1 Protein

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Chaperone-Mediated Autophagy in Neurodegeneration

ZFYVE26 Gene

Circadian Rhythm Modulation Therapy

Pathway Diagram

Outgoing (1125)

Incoming (1224)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

Digital biomarkers and AI-driven early detection of neurodegeneration

Mechanistic role of APOE in neurodegeneration

Related Papers (11)