gene

SQSTM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SQSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4029Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

SQSTM1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with AD, ADH, ALI. Connected to 2085 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SQSTM1
Full Name	SQSTM1 (p62/Sequestosome-1)
Chromosome	5q35.3.
Protein Type	Protein
Function	p62/SQSTM1 functions as: [@jones2021]
Molecular Weight	~62 kDa (hence p62)
Pathways	Adaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle
UniProt ID	Q13501
GeneCards	SQSTM1
Human Protein Atlas	SQSTM1
P392L	the most common mutation, originally identified in Paget disease of bone and subsequently linked to ALS
L341V, P348L	affect the LIR domain, disrupting LC3 binding
K238E, D337E	impair NF-κB signaling or autophagy flux
Associated Diseases	AD, ADH, ALI, ALS, AMI, ARM
Known Drugs/Compounds	RAPAMYCIN, Ubiquitinated Proteins, Ubiquitinated Cargo, Ubiquitinated Substrates, statins, COENZYME Q10
Interactions	ABCA1, APOE, LOX, NDP52, TAX1BP1, FUS
KG Connections	4026 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SQSTM1 — AlphaFold Q13501 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Signaling["Signaling"]
        SQSTM1["SQSTM1"] -->|"activates"| NFE2L2["NFE2L2"]
        SQSTM1["SQSTM1"] -->|"regulates"| Autophagy["Autophagy"]
        SQSTM1["SQSTM1"] -->|"regulates"| Cancer["Cancer"]
        SQSTM1["SQSTM1"] -->|"activates"| Autophagy_3["Autophagy"]
        SQSTM1["SQSTM1"] -->|"activates"| Tumor["Tumor"]
        SQSTM1["SQSTM1"] -->|"activates"| Als_4["Als"]
        LC3["LC3"] -->|"activates"| SQSTM1["SQSTM1"]
        KEAP1["KEAP1"] -->|"activates"| SQSTM1["SQSTM1"]
        P62["P62"] -->|"activates"| SQSTM1["SQSTM1"]
        BECN1["BECN1"] -->|"activates"| SQSTM1["SQSTM1"]
        MITOPHAGY["MITOPHAGY"] -->|"activates"| SQSTM1["SQSTM1"]
    end
    subgraph Interactions["Interactions"]
        SQSTM1["SQSTM1"] -->|"interacts with"| Autophagy_1["Autophagy"]
    end
    subgraph Pathology["Pathology"]
        SQSTM1["SQSTM1"] -->|"associated with"| Autophagy_2["Autophagy"]
        SQSTM1["SQSTM1"] -->|"associated with"| Als["Als"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| SQSTM1["SQSTM1"]
    end
    style SQSTM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style NFE2L2 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy_3 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style KEAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2119)

Target	Relation	Type	Str
P62	associated_with	gene	1.00
P62	activates	gene	1.00
NRF2	activates	gene	1.00
P62	regulates	gene	1.00
P62	encodes	protein	1.00
Autophagy	regulates	pathway	1.00
Autophagy	interacts_with	pathway	1.00
Autophagy	associated_with	pathway	1.00
Als	associated_with	disease	1.00
Cancer	regulates	disease	1.00
Autophagy	activates	pathway	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Als	inhibits	disease	1.00
Inflammation	activates	disease	1.00
Mtor	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Als	regulates	disease	1.00
Mitophagy	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
AUTOPHAGY	associated_with	gene	1.00
Cancer	activates	disease	1.00
MITOCHONDRIA	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
NFE2L2	activates	protein	1.00
MTOR	activates	protein	1.00
LC3	activates	gene	1.00
OPTN	associated_with	gene	1.00
Autophagy	inhibits	pathway	1.00
ALS	associated_with	disease	1.00
ATG	associated_with	gene	1.00
Als	implicated_in	disease	1.00
Oxidative Stress	activates	pathway	1.00
CANCER	activates	gene	1.00
STING	mediates	entity	0.95
Α-SYNUCLEIN	mediates	entity	0.95
AUTOPHAGY	mediates	entity	0.95
Mitochondrial Ubiquitination	associated_with	process	0.95
Selective Autophagy	mediates	process	0.95
Frontotemporal Lobar Degeneration	risk_factor_for	disease	0.95
Paget's Disease of Bone	associated_with	disease	0.95
Lipophagy	mediates	process	0.95
P392L	associated_with	variant	0.95
Aβ Clearance	involved_in	process	0.95
Als	interacts_with	disease	0.95
Tumor	associated_with	disease	0.95
Neurodegeneration	activates	disease	0.95
Neurodegeneration	regulates	disease	0.95
Als	therapeutic_target	disease	0.95
Cancer	therapeutic_target	disease	0.95

Incoming (1910)

Source	Relation	Type	Str
LC3	activates	gene	1.00
KEAP1	activates	gene	1.00
P62	activates	gene	1.00
BECN1	activates	gene	1.00
MTOR	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
LYSOSOME	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
ROS	activates	gene	1.00
AMPK	activates	gene	0.98
ALS	activates	disease	0.98
ALZHEIMER'S DISEASE	associated_with	disease	0.98
Menin	regulates	protein	0.97
RAPAMYCIN	activates	drug	0.95
Metabolic Stress	upregulates	process	0.95
S-acylation	associated_with	mechanism	0.95
BHB	downregulates	compound	0.95
MAP1LC3A	interacts_with	protein	0.95
ACOD1	interacts_with	gene	0.92
P2RY12	inhibits	entity	0.90
CSNK1A1	phosphorylates	entity	0.90
amyloid beta	contributes_to	protein	0.90
Nfkb	upregulates	pathway	0.90
NFE2L2	upregulates	gene	0.90
PINK1	upstream_of	gene	0.90
Amyloid Beta	upregulates	protein	0.90
RNA	activates	gene	0.90
MAP1LC3	regulates	gene	0.90
rapamycin	targets	drug	0.90
TBK1	phosphorylates	protein	0.90
ULK1	phosphorylates	protein	0.90
ALS-FTLD mutations	modifies	phenotype	0.90
PPARGC1A	regulates	protein	0.90
autophagy	regulates	pathway	0.90
PB1 Domain	mediates	mechanism	0.90
STOCK1N-57534	activates	drug	0.90
ATC161	binds	drug	0.90
I344E Mutation	upregulates	variant	0.90
Rapamycin	downregulates	drug	0.90
CKLF	contributes_to	protein	0.90
MAP1LC3	binds	gene	0.90
TRIM21	inhibits	protein	0.90
SESTRIN2	interacts_with	protein	0.90
AMPK	upregulates	protein	0.90
PINK1	regulates	gene	0.90
NEURODEGENERATION	activates	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SQSTM1

Understanding Entity Pages

Summary

Wiki Pages (21)

p62/SQSTM1 (Sequestosome-1)

cbs-psp-daily-action-plan

neuroinflammation

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Mitochondrial Quality Control

Pathway Diagram

Outgoing (2119)

Incoming (1910)

Targeting Hypotheses (0)

Mentioning Analyses (3)

What determines the spatial organization of autophagy receptors at stress granul

Tau propagation mechanisms and therapeutic interception points

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Related Papers (0)

SQSTM1

Understanding Entity Pages

Summary

Wiki Pages (21)

p62/SQSTM1 (Sequestosome-1)

cbs-psp-daily-action-plan

neuroinflammation

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Mitochondrial Quality Control

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

dimethyl-fumarate-nrf2-ad-nct06850597

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

proteasome-ubiquitin-system-dysfunction-parkinsons

mitophagy-defect

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

FOXO1 Protein

NF-kB Signaling Pathway in Neurodegeneration

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Chaperone-Mediated Autophagy in Neurodegeneration

ZFYVE26 Gene

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Pathway Diagram

Outgoing (2119)

Incoming (1910)

Targeting Hypotheses (0)

Mentioning Analyses (3)

What determines the spatial organization of autophagy receptors at stress granul

Tau propagation mechanisms and therapeutic interception points

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Related Papers (0)