Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SQSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SQSTM1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with AD, ADH, ALI. Connected to 2085 entities in the SciDEX knowledge graph.
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| Gene Symbol | SQSTM1 |
| Full Name | Sequestosome 1 (p62) |
| Chromosome | 5q35.3. |
| Protein Type | Protein |
| Function | p62/SQSTM1 functions as: [@jones2021] |
| Molecular Weight | ~62 kDa (hence p62) |
| Pathways | Adaptive Immunity, Akt, Autophagy, Autophagy-lysosomal pathway, Cell Cycle |
| UniProt ID | Q13501 |
| GeneCards | SQSTM1 |
| Human Protein Atlas | SQSTM1 |
| Associated Diseases | AD, ADH, Aging, ALI, Als |
| Known Drugs/Compounds | ATC161, COENZYME Q10, DEXAMETHASONE, N-degrons, Palmostatin B, rapamycin |
| Interactions | 4E-BP1, ABCA1, ABCD3, ABCG1, ACAT1, ACHE |
| SciDEX Hypotheses | Rutin enhances chaperone and autophagic clearance Astrocytic SQSTM1 Overexpression Therapy Cross-Seeding Autophagy Specificity Enhancement |
| KG Connections | 4054 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
SQSTM1["SQSTM1"] -->|"activates"| NFE2L2["NFE2L2"]
SQSTM1["SQSTM1"] -->|"regulates"| Autophagy["Autophagy"]
SQSTM1["SQSTM1"] -->|"regulates"| Cancer["Cancer"]
SQSTM1["SQSTM1"] -->|"activates"| Autophagy_3["Autophagy"]
SQSTM1["SQSTM1"] -->|"activates"| Tumor["Tumor"]
SQSTM1["SQSTM1"] -->|"activates"| Als_4["Als"]
LC3["LC3"] -->|"activates"| SQSTM1["SQSTM1"]
KEAP1["KEAP1"] -->|"activates"| SQSTM1["SQSTM1"]
P62["P62"] -->|"activates"| SQSTM1["SQSTM1"]
BECN1["BECN1"] -->|"activates"| SQSTM1["SQSTM1"]
MITOPHAGY["MITOPHAGY"] -->|"activates"| SQSTM1["SQSTM1"]
end
subgraph Interactions["Interactions"]
SQSTM1["SQSTM1"] -->|"interacts with"| Autophagy_1["Autophagy"]
end
subgraph Pathology["Pathology"]
SQSTM1["SQSTM1"] -->|"associated with"| Autophagy_2["Autophagy"]
SQSTM1["SQSTM1"] -->|"associated with"| Als["Als"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| SQSTM1["SQSTM1"]
end
style SQSTM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style NFE2L2 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_3 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style KEAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NFE2L2 | activates | protein | 1.00 |
| Als | regulates | disease | 1.00 |
| NRF2 | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| P62 | regulates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Tumor | activates | disease | 1.00 |
| P62 | encodes | protein | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| P62 | associated_with | gene | 1.00 |
| autophagy | regulates | process | 1.00 |
| Autophagy | interacts_with | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| MTOR | activates | protein | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| ATG | associated_with | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| ALS | associated_with | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| OPTN | associated_with | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| STING Degradation | mediates | process | 0.95 |
| Neurodegeneration | activates | disease | 0.95 |
| Als | interacts_with | disease | 0.95 |
| Mitochondrial Ubiquitination | associated_with | process | 0.95 |
| Als | therapeutic_target | disease | 0.95 |
| CDKN2A | mediates | protein | 0.95 |
| Neurodegeneration | regulates | disease | 0.95 |
| Cytosolic Accumulation | associated_with | phenotype | 0.95 |
| polyQ aggregates | binds_to | phenotype | 0.95 |
| P392L | associated_with | variant | 0.95 |
| Aggrephagy | involved_in | process | 0.95 |
| Aβ Clearance | involved_in | process | 0.95 |
| Lipophagy | mediates | process | 0.95 |
| STING | mediates | entity | 0.95 |
| CDKN1A | mediates | protein | 0.95 |
| Ubiquitinated Substrates | interacts_with | compound | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | activates | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| LYSOSOME | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| BECN1 | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| ALS | activates | disease | 0.98 |
| AMPK | activates | gene | 0.98 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.98 |
| Menin | regulates | protein | 0.97 |
| S-acylation | associated_with | mechanism | 0.95 |
| Metabolic Stress | upregulates | process | 0.95 |
| BHB | downregulates | compound | 0.95 |
| RAPAMYCIN | activates | drug | 0.95 |
| MAP1LC3A | interacts_with | protein | 0.95 |
| ACOD1 | interacts_with | gene | 0.92 |
| PPARGC1A | regulates | protein | 0.90 |
| Nfkb | upregulates | pathway | 0.90 |
| AMPK | upregulates | protein | 0.90 |
| MAP1LC3 | regulates | gene | 0.90 |
| RNA | activates | gene | 0.90 |
| rapamycin | targets | drug | 0.90 |
| NFE2L2 | upregulates | gene | 0.90 |
| PINK1 | associated_with | gene | 0.90 |
| SESTRIN2 | interacts_with | protein | 0.90 |
| TBK1 | phosphorylates | gene | 0.90 |
| STOCK1N-57534 | activates | drug | 0.90 |
| autophagy | regulates | pathway | 0.90 |
| Amyloid Beta | upregulates | protein | 0.90 |
| MAP1LC3 | associated_with | gene | 0.90 |
| amyloid beta | contributes_to | protein | 0.90 |
| ALS-FTLD mutations | modifies | phenotype | 0.90 |
| P2RY12 | inhibits | entity | 0.90 |
| TBK1 | phosphorylates | protein | 0.90 |
| CKLF | contributes_to | protein | 0.90 |
| ULK1 | phosphorylates | protein | 0.90 |
| CSNK1A1 | phosphorylates | entity | 0.90 |
| ATC161 | binds | drug | 0.90 |
| I344E Mutation | upregulates | variant | 0.90 |
| PB1 Domain | mediates | mechanism | 0.90 |
| Rapamycin | downregulates | drug | 0.90 |
| TRIM21 | inhibits | protein | 0.90 |
| PINK1 | regulates | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Rutin enhances chaperone and autophagic clearance of misfold | 0.599 | neurodegeneration | What is the molecular mechanism by which |
| CHIP-mediated K63-linked ubiquitination redirects oligomeric | 0.380 | protein-biochemistry | Do chaperones selectively recognize path |
| CHIP-mediated K63-linked ubiquitination promotes autophagoso | 0.380 | protein-biochemistry | Do chaperones selectively recognize path |
| Cross-Seeding Autophagy Specificity Enhancement | 0.000 | - | Autophagy-lysosome pathway convergence a |
| Astrocytic SQSTM1 Overexpression Therapy | 0.000 | - | How do non-cell autonomous effects of au |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387
neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.627
neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390
neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633
neurodegeneration | 2026-04-04 | 18 hypotheses Top: 0.814
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
completed · Rounds: 5 · Score: 0.50 · 2026-04-25
closed · Rounds: 4 · Score: 0.66 · 2026-04-25
closed · Rounds: 4 · Score: 0.69 · 2026-04-21
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.71 · 2026-04-12
closed · Rounds: 4 · Score: 0.94 · 2026-04-10
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
closed · Rounds: 4 · Score: 0.81 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning SQSTM1 in their description or question text
No additional research found