gene

SIGLEC10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGLEC10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

3Outgoing

3Incoming

Summary

Page for SIGLEC10 — Sialic Acid Binding Ig-Like Lectin 10

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🧬 Gene Info

Gene Symbol	SIGLEC10
Full Name	Sialic Acid Binding Ig-Like Lectin 10
Chromosome	19q13.4
Function	is a member of the Siglec family of cell surface lectins that recognize sialic acid residues on glycoconjugates.
Primary Expression	B cells, monocytes, eosinophils, dendritic cells
Molecular Weight	~60 kDa
Amino Acids	553 aa
Exons	12
UniProt ID	Q9H7M1
NCBI Gene ID	89792
GeneCards	SIGLEC10
Human Protein Atlas	SIGLEC10
Feature	Value
Genomic Coordinates	chr19:50,884,231-50,901,213 (GRCh38)
Exon Count	12
Associated Diseases	Glioma
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIGLEC10 — AlphaFold Q9H7M1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    SIGLEC10(["SIGLEC10"])
    Tumor_Immune_Escape["Tumor Immune Escape"]
    Macrophage_Phagocytosis("Macrophage Phagocytosis")
    CD24(["CD24"])
    ITGA3(["ITGA3"])
    ITGB1(["ITGB1"])
    Glioma["Glioma"]
    Inflammatory_Mediators("Inflammatory Mediators")
    neurodegeneration["neurodegeneration"]

    SIGLEC10 -->|"mediates"| Tumor_Immune_Escape
    SIGLEC10 -.->|"inhibits"| Macrophage_Phagocytosis
    CD24 -->|"binds"| SIGLEC10
    ITGA3 -->|"binds"| SIGLEC10
    ITGB1 -->|"binds"| SIGLEC10
    SIGLEC10 -->|"associated with"| Glioma
    SIGLEC10 -->|"associated with"| Inflammatory_Mediators
    SIGLEC10 -->|"implicated in"| neurodegeneration

    style SIGLEC10 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Tumor Immune Escape	mediates	mechanism	0.80
Macrophage Phagocytosis	inhibits	biological_process	0.80
Glioma	associated_with	disease	0.70

Incoming (3)

Source	Relation	Type	Str
ITGA3	binds	gene	0.80
CD24	binds	gene	0.80
ITGB1	binds	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found