Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRPα: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Cle | 0.510 | immunomics | Systemic immune profiling in neurodegene |
| Microglial Membrane Camouflage Exploits CD47-SIRPα Checkpoin | 0.444 | neuroinflammation | How does Alectinib, a kinase inhibitor, |
Scientific analyses that reference this entity
drug delivery | 2026-04-15 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Microglia-specific SIRPα deletion in conditional knockout mice | validation | 0.900 | 0.00 | conditional knockout mice | proposed | N/A | |
| SIRPα modulation in mouse models of Alzheimer's disease | validation | Alzheimer's disease | 0.900 | 0.00 | mouse models of Alzheimer's di | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning SIRPα in their description or question text
No additional research found