protein

CD47

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD47: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

386Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CD47 is a protein involved in neurodegeneration research. Key relationships include: regulates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 160 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CD47
Chromosome	3q13.1
Function	CD47 is a transmembrane protein that acts as a "don't eat me" signal by binding to SIRPα on macrophages and other phagocytic cells.
Primary Expression	various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis
Amino Acids	323 aa
Pathways	Adaptive Immunity, Amyloid, Apoptosis, Complement, Endocytosis
Ensembl ID	ENSG00000196776
GeneCards	CD47
Human Protein Atlas	CD47
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Glioblastoma
Interactions	GFAP, MMP9, TNF, TLR4, CD68, MMP2
KG Connections	386 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD47["CD47"]
    CD47 -->|"regulates"| Inflammation["Inflammation"]
    CD47 -->|"regulates"| Als["Als"]
    CD47 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CD47 -->|"regulates"| Aging["Aging"]
    CD47 -->|"regulates"| Alzheimer["Alzheimer"]
    CD47 -->|"regulates"| Autism["Autism"]
    CD47 -->|"regulates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    CD47 -->|"regulates"| Depression["Depression"]
    CD47 -->|"inhibits"| Ms["Ms"]
    CX3CR1["CX3CR1"] -->|"regulates"| CD47
    C1Q["C1Q"] -->|"regulates"| CD47
    S100A8["S100A8"] -->|"inhibits"| CD47
    OVERVIEW["OVERVIEW"] -->|"regulates"| CD47
    CD68["CD68"] -->|"inhibits"| CD47
    TNF["TNF"] -->|"inhibits"| CD47
    RAGE["RAGE"] -->|"interacts"| CD47
    CD19["CD19"] -->|"target for"| CD47
    MICROGLIA["MICROGLIA"] -->|"target for"| CD47

Outgoing (249)

Target	Relation	Type	Str
Neutrophil Extracellular Traps Formation	inhibits	process	0.95
macrophage phagocytosis	inhibits	process	0.93
SIRPα	binds	receptor	0.90
neutrophil extracellular traps formation	inhibits	process	0.90
S100A8/A9	downregulates	protein	0.85
Phagocytosis	suppresses	process	0.85
Neutrophil Extracellular Traps	inhibits	biological_process	0.80
neutrophil extracellular traps	interferes_with	process	0.80
microglia	expressed_in	cell_type	0.80
Depression	regulates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
complement cascade	participates_in	pathway	0.70
Phagocytosis	therapeutic_target	pathway	0.70
neurons	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Spinal Cord Injury	inhibits	disease	0.65
Retinal Degeneration	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Autism	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Glioblastoma	associated_with	disease	0.65
ALS	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Leukemia	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Inflammation	causes	disease	0.65
Medulloblastoma	causes	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Infection	regulates	disease	0.65

Incoming (137)

Source	Relation	Type	Str
MYC	transcriptionally_regulates	gene	0.92
Lactate	upregulates	compound	0.90
EGFR	promotes	gene	0.90
Histone Lactylation	upregulates	process	0.90
MYC	binds_to	gene	0.88
Galectin-3	associated_with	protein	0.80
DEPRESSION	regulates	gene	0.70
PHAGOCYTOSIS	therapeutic_target	gene	0.70
LACTATE	activates	phenotype	0.65
LACTATE	causes	phenotype	0.65
LACTATE	regulates	phenotype	0.65
CX3CR1	regulates	gene	0.60
C1Q	regulates	gene	0.60
S100A8	inhibits	gene	0.60
OVERVIEW	regulates	gene	0.60
CD68	inhibits	gene	0.60
TNF	inhibits	gene	0.60
RAGE	interacts_with	gene	0.60
CD36	associated_with	gene	0.60
CD14	associated_with	gene	0.60
CD19	therapeutic_target	gene	0.60
TLR4	inhibits	gene	0.60
TLR4	associated_with	gene	0.60
MMP2/MMP9	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
CMKLR1	interacts_with	gene	0.60
TLR2	associated_with	gene	0.60
GBM	therapeutic_target	gene	0.60
CD36	inhibits	gene	0.60
TGM2	causes	gene	0.60
PKC	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
SNAP25	regulates	gene	0.60
GEPHYRIN	regulates	gene	0.60
C1Q	associated_with	gene	0.60
ARC	regulates	gene	0.60
CD8	regulates	gene	0.60
CGAS	activates	gene	0.60
C1Q	activates	entity	0.60
GBM	activates	gene	0.60
EP300	activates	gene	0.60
C1QB	regulates	gene	0.60
C1R	regulates	gene	0.60
SIRPA	regulates	gene	0.60
C1QC	regulates	gene	0.60
C1S	regulates	gene	0.60
MERTK	regulates	gene	0.60
ITGAM	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD47

Understanding Entity Pages

Summary

Wiki Pages (21)

CD47 Gene

Therapeutics

Extracellular Vesicles in Neurodegeneration

microglial-synaptic-pruning-dysregulation

Exosome Biogenesis in Neurodegeneration

CBS Microglial Neuroimmune Axis

Efferocytosis in Neurodegeneration

Neuroimmune Checkpoint Pathway

Emerging Research Directions in Neurodegeneration

Vaccinex, Inc.

NLRP3 Senomorphic Cycling Therapy

CR3-Dependent Microglial Synapse Elimination in Parkinson's Disease

Innate Immune Response in Neurodegeneration

Neuroimmune Checkpoint-Metal-Oxidative Stress Convergence Synthesis

AD Microglial Phagocytosis and Synaptic Pruning Companies

GEPHYRIN

AD Neuroimmune Checkpoint and TREM2 Pathway Companies

Emerging Therapeutic Directions 2025-2026

CD47-SIRPα Immune Checkpoint Therapy