gene

slc2a3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about slc2a3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections
0Hypotheses
0Analyses
2Outgoing
1Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolSLC2A3
Full NameSolute Carrier Family 2 Member 3 (GLUT3)
Chromosome12p13.31
Protein FamilyMajor Facilitator Superfamily (MFS)
Functionencodes GLUT3 (Glucose Transporter 3), a high-affinity glucose transporter with the highest uptake capacity among GLUT family members
Primary Expressionneurons, particularly in regions with high metabolic demand including the cerebral cortex, hippocampus, and cerebellar Purkinje cells
UniProt IDP11166
NCBI Gene ID6503
Ensembl IDENSG00000146670
OMIM138170
GeneCardsSLC2A3
Human Protein AtlasSLC2A3
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: slc2a3 — AlphaFold P11166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Astrocyte-Neuron Metabolic Coupling Pathway

mechanism · 3060 words

Metabolic Dysfunction in Alzheimer's Disease

mechanism · 3005 words

Metabolic Dysfunction in 4R-Tauopathies

mechanism · 2556 words

SLC2A1 Gene

gene · 2479 words

Pathway Diagram

flowchart TD
    SLC2A3["SLC2A3"] -->|"promotes"| glucose_uptake["glucose uptake"]
    SLC2A3["SLC2A3"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
    Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    GLUCOSE_UPTAKE["GLUCOSE UPTAKE"] -->|"expressed in"| MUSCLE["MUSCLE"]
    TUG["TUG"] -->|"regulates"| Glucose_Uptake["Glucose Uptake"]
    Insulin_Stimulated_TUG_Cleavag["Insulin-Stimulated TUG Cleavage"] -->|"upregulates"| Glucose_Uptake["Glucose Uptake"]
    ASPSCR1["ASPSCR1"] -->|"promotes"| Glucose_Uptake["Glucose Uptake"]
    style SLC2A3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style glucose_uptake fill:#5d4400,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
    style GLUCOSE_UPTAKE fill:#006494,stroke:#333,color:#e0e0e0
    style MUSCLE fill:#006494,stroke:#333,color:#e0e0e0
    style TUG fill:#006494,stroke:#333,color:#e0e0e0
    style Glucose_Uptake fill:#5d4400,stroke:#333,color:#e0e0e0
    style Insulin_Stimulated_TUG_Cleavag fill:#1b5e20,stroke:#333,color:#e0e0e0
    style ASPSCR1 fill:#006494,stroke:#333,color:#e0e0e0

Outgoing (2)

TargetRelationTypeStr
glucose uptakepromotesprocess0.90
benchmark_ot_ad_answer_key:SLC2A3data_indataset_row0.00

Incoming (1)

SourceRelationTypeStr
benchmark_ot_ad_answer_key:SLC2A3data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found