Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC30A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ZnT1 - Zinc transporter essential for zinc homeostasis and implicated in neurodegeneration
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| Gene Symbol | SLC30A1 |
| Aliases | ZnT1 |
| Function | ZnT1 plays a critical role in protecting cells from zinc toxicity while also ensuring adequate zinc supply for essential cellular functions. |
| Primary Expression | neurons, astrocytes, and the blood-brain barrier, where it contributes to zinc homeostasis in the [central nervous system](/brain-regions/central-nerv |
| Subcellular Localization | affects transport activity |
| Amino Acids | 501 aa |
| Ensembl ID | ENSG00000170370 |
| GeneCards | SLC30A1 |
| Human Protein Atlas | SLC30A1 |
| Six transmembrane domains | Form the transport channel |
| N- and C-terminal tails | Located in the cytoplasm |
| Histidine-rich loop | Between TM4 and TM5 (involved in zinc binding) |
| Dimerization | Functions as a homodimer 5 |
| Zinc-dependent | MTF-1 (metal-responsive transcription factor-1) activates transcription under zinc deficiency |
| Cellular zinc status | Zinc-responsive promoter elements control expression |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SLC30A1["SLC30A1"]
neurodegeneration["neurodegeneration"]
SLC30A1 -->|"implicated_in"| neurodegeneration
style SLC30A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC30A1 in their description or question text
No additional research found