gene

SLC39A12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC39A12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ZIP12 is a zinc transporter highly expressed in the brain, implicated in neuronal development, synaptic function, and neuropsychiatric disorders.

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🧬 Gene Info

Gene Symbol	SLC39A12
Full Name	Solute Carrier Family 39 Member 12 (ZIP12)
Aliases	ZIP12, LZT8
Chromosome	9q34.2
Protein Family	SLC39A (ZIP) transporter family
Protein Type	Transporter
Function	is a member of the solute carrier family 39 (ZIP) metal transporters.
Primary Expression	High in brain (cortex, hippocampus); moderate in testis
Subcellular Localization	Plasma membrane
Amino Acids	628 aa
GeneCards	SLC39A12
Human Protein Atlas	SLC39A12
Protein Length	628 amino acids
Brain Region	Expression Level
Cerebral Cortex	High
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC39A12["SLC39A12"]
    neurodegeneration["neurodegeneration"]
    SLC39A12 -->|"implicated_in"| neurodegeneration
    style SLC39A12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found