gene

SLC9A3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLC9A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive analysis of SLC9A3 gene, encoding NHE3, involved in sodium hydrogen exchange, acid-base balance, and implications for neurodegenerative diseases and transport physiology.

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🧬 Gene Info

Gene Symbol	SLC9A3
Full Name	Solute Carrier Family 9 Member 3 (Na+/H+ Exchanger 3)
Chromosome	5p15.33
Function	encodes a protein of approximately 834 amino acids that functions as an electrogenic sodium/hydrogen antiporter.
Primary Expression	the epithelial cells of the kidney and intestine, where it plays a critical role in sodium reabsorption and acid-base balance
Molecular Weight	93 kDa
Amino Acids	834 aa
Exons	17
UniProt ID	O75345
NCBI Gene ID	6540
Ensembl ID	ENSG00000110002
OMIM	607048
GeneCards	SLC9A3
Human Protein Atlas	SLC9A3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC9A3 — AlphaFold O75345 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC9A3 — Solute Carrier Family 9 Member 3 (Na+/H+ Exchanger 3)

gene · 2366 words

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Pathway Diagram

graph TD
    SLC9A3["SLC9A3"]
    neurodegeneration["neurodegeneration"]
    SLC9A3 -->|"implicated_in"| neurodegeneration
    style SLC9A3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC9A3 in their description or question text

No additional research found