gene

SPG30

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SPG30: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SPG30 (SAT1) encodes spermidine/spermine N1-acetyltransferase, a key enzyme in polyamine metabolism linked to hereditary spastic paraplegia type 30

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🧬 Gene Info

Gene Symbol	SPG30
Full Name	Spermidine/Spermine N1-Acetyltransferase 1
Chromosome	2q37.3
Protein Family	Acetyltransferase family
Protein Type	Enzyme
Function	is a metabolic enzyme that plays a critical role in polyamine metabolism.
Amino Acids	171 aa
UniProt ID	Q96EY8
NCBI Gene ID	550631
OMIM	610362
GeneCards	SPG30
Human Protein Atlas	SPG30
Substrate specificity	High affinity for spermidine and spermine
Kinetics	Low Km values for polyamine substrates
Regulation	Enzyme activity is highly inducible in response to polyamine levels
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPG30 — AlphaFold Q96EY8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SPG30 Gene

gene · 1341 words

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Pathway Diagram

graph TD
    SPG30["SPG30"]
    neurodegeneration["neurodegeneration"]
    SPG30 -->|"implicated_in"| neurodegeneration
    style SPG30 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SPG30 in their description or question text

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