gene

STX8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Syntaxin 8 - an endosomal SNARE protein involved in vesicle trafficking, autophagy, and neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	STX8
Full Name	Syntaxin 8
Chromosome	17p12
Protein Family	Q-SNARE (Syntaxin family)
Function	is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family specialized for endosomal trafficking pathways.
Molecular Weight	25 kDa
Amino Acids	70 aa
UniProt ID	[Q9UNK0](https://www.uniprot.org/uniprot/Q9UNK0)
Ensembl ID	ENSG00000143171
OMIM	604279
GeneCards	STX8
Human Protein Atlas	STX8
Q-SNAREs	STX8, STX7, VTI1B
R-SNAREs	VAMP8, VAMP7, YKT6
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["STX8"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity