Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SV2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SV2C (Synaptic Vesicle Glycoprotein 2C) protein enriched in dopaminergic neurons, role in Parkinson's disease and synaptic vesicle function
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| Gene Symbol | SV2C |
| Full Name | Synaptic Vesicle Glycoprotein 2C |
| Chromosome | 5q13.2 |
| Function | The SV2C gene encodes Synaptic Vesicle Glycoprotein 2C, a member of the SV2 family of proteins that are essential components of synaptic vesicles. |
| Primary Expression | various regions including the basal ganglia, cortex, hippocampus, and cerebellum |
| Molecular Weight | 82 kDa |
| Amino Acids | 200 aa |
| UniProt ID | Q9H0Y9 |
| NCBI Gene ID | 22983 |
| Ensembl ID | ENSG00000170873 |
| OMIM | 610516 |
| GeneCards | SV2C |
| Human Protein Atlas | SV2C |
| GWAS associations | Multiple studies have identified SV2C variants (rs1871678, rs6474359) as risk factors for sporadic PD |
| Mechanism | SV2C modulates synaptic vesicle filling and priming, affecting dopamine release capacity |
| Associated Diseases | Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SV2C["SV2C"]
neurodegeneration["neurodegeneration"]
SV2C -->|"implicated_in"| neurodegeneration
style SV2C fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning SV2C in their description or question text
No additional research found