Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPTIC_DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| early_AD | biomarker_for | disease | 0.70 |
| neurodegeneration | contributes_to | phenotype | 0.64 |
| COGNITIVE_IMPAIRMENT | causes | phenotype | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| protein_oligomers | causes | protein | 0.72 |
| neuroinflammation | causes | mechanism | 0.70 |
| C3 | causes | protein | 0.64 |
| CA2 | causes | protein | 0.64 |
| PROTEIN_MISFOLDING | causes | phenotype | 0.64 |
| C1Q | causes | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop optogenetic targeting PV interneurons to restore | 0.959 | alzheimers | Circuit-level neural dynamics in neurode |
| Excitatory Neuron Synaptic Dysfunction and Mitochondrial Str | 0.660 | neurodegeneration | Cell type vulnerability debate in Alzhei |
| SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs | 0.652 | neurodegeneration | What are the specific PTM changes in syn |
| Dysregulated G3BP1 Signaling Impairs Local Translation in Ne | 0.580 | neurodegeneration | How do disease-associated mutations in G |
| TFEB Family-Wide Activation to Restore Lysosomal Networks in | 0.380 | proteomics | Quantitative proteomics of the aging syn |
| Mitochondrial Transfer Enhancers for Synaptic Dysfunction | 0.000 | - | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 20 hypotheses Top: 0.651
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037] | ["Musi Nicolas", "Valentine Joseph M", " | Aging cell | 2018 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037] | ["Musi Nicolas", "Valentine Joseph M", " | Aging cell | 2018 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
Hypotheses and analyses mentioning SYNAPTIC_DYSFUNCTION in their description or question text