Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPTIC_DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | contributes_to | phenotype | 0.64 |
| COGNITIVE_IMPAIRMENT | causes | phenotype | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| protein_oligomers | causes | protein | 0.72 |
| C3 | causes | protein | 0.64 |
| CA2 | causes | protein | 0.64 |
| PROTEIN_MISFOLDING | causes | phenotype | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop optogenetic targeting PV interneurons to restore | 0.633 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs | 0.552 | neurodegeneration | What are the specific PTM changes in syn |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.552
proteomics | 2026-04-16 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||