Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SYNE1 |
| Full Name | Spectrin Repeat Containing Nuclear Envelope Protein 1 |
| Aliases | Page for SYNE1 Gene |
| Chromosome | 6q25.1 |
| Function | SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) encodes nesprin-1, a giant protein involved in nuclear envelope organization and cytoskeletal linkages |
| Molecular Weight | 879 kDa |
| UniProt ID | Q8NF91 |
| NCBI Gene ID | 23345 |
| Ensembl ID | ENSG00000188352 |
| OMIM | 608441 |
| GeneCards | SYNE1 |
| Human Protein Atlas | SYNE1 |
| N-terminal actin-binding domain | Binds γ-actin and β-actin |
| Spectrin repeats | 56-74 spectrin repeats forming a flexible rod domain |
| Nuclear envelope targeting domain | KASH domain for nuclear membrane localization |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SYNE1["SYNE1"]
neurodegeneration["neurodegeneration"]
SYNE1 -->|"implicated_in"| neurodegeneration
style SYNE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SYNE1 in their description or question text
No additional research found