protein

SYNGAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNGAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

1Hypotheses

1Analyses

3Outgoing

1Incoming

0Experiments

2Debates

Summary

Page for SynGAP Protein

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🔬 Protein Info

Gene Symbol	SYNGAP
Molecular Weight	134 kDa
GeneCards	SYNGAP
Human Protein Atlas	SYNGAP
Interactions	NMDA, PSD-95
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

SYNGAP1-Related Epilepsy

disease · 1335 words

→

SYNGAP1 — Synaptic Ras GTPase Activating Protein 1

gene · 1297 words

→

Pathway Diagram

graph TD
    SYNGAP(["SYNGAP"])
    GLUTAMATE["GLUTAMATE"]
    PSD_95(["PSD-95"])
    SYNAPSE["SYNAPSE"]
    NMDA(["NMDA"])

    SYNGAP -->|"activates"| GLUTAMATE
    SYNGAP -->|"interacts with"| PSD_95
    SYNGAP -->|"interacts with"| SYNAPSE
    NMDA -->|"activates"| SYNGAP

    style SYNGAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style GLUTAMATE fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff
    style PSD_95 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style SYNAPSE fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff
    style NMDA fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
GLUTAMATE	activates	concept	0.50
PSD-95	interacts_with	protein	0.50
SYNAPSE	interacts_with	concept	0.50

Incoming (1)

Source	Relation	Type	Str
NMDA	activates	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.683	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.683

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Debate: Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

This study reveals SYNGAP1 expression and function in radial glia before synapto

closed · Rounds: 4 · Score: 0.78 · 2026-04-16

Related Research

Hypotheses and analyses mentioning SYNGAP in their description or question text

No additional research found