concept

GLUTAMATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUTAMATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

533Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GLUTAMATE
Summary	Glutamate as a biomarker for excitotoxicity in Alzheimer's, Parkinson's, and ALS
Key Genes/Proteins	TAU, AMYLOID, APOE, NF-KB, APP, AKT
Related Diseases	ALZHEIMER'S DISEASE, ALS, PARKINSON'S DISEASE, EXCITOTOXICITY
Linked Hypotheses	1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GLUTAMATE["GLUTAMATE"]
    GLUTAMATE -->|"causes"| Excitotoxicity["Excitotoxicity"]
    GLUTAMATE -->|"inhibits"| SYSTEM_XC_["SYSTEM XC-"]
    GLUTAMATE -->|"causes"| EXCITOTOXICITY["EXCITOTOXICITY"]
    GLUTAMATE -->|"causes"| excitotoxicity["excitotoxicity"]
    GLUTAMATE -->|"causes"| motor_neuron["motor neuron"]
    GLUTAMATE -->|"activates"| neurodegeneration["neurodegeneration"]
    GLUTAMATE -->|"interacts"| NF_KB["NF-KB"]
    GLUTAMATE -->|"inhibits"| AXONS["AXONS"]
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| GLUTAMATE
    MACROPHAGES["MACROPHAGES"] -->|"activates"| GLUTAMATE
    MITOPHAGY["MITOPHAGY"] -->|"activates"| GLUTAMATE
    PARKIN["PARKIN"] -->|"activates"| GLUTAMATE
    PINK1["PINK1"] -->|"activates"| GLUTAMATE
    PTEN["PTEN"] -->|"activates"| GLUTAMATE
    UBIQUITIN["UBIQUITIN"] -->|"activates"| GLUTAMATE
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| GLUTAMATE
    NEURODEGENERATION["NEURODEGENERATION"] -->|"inhibits"| GLUTAMATE

Outgoing (134)

Target	Relation	Type	Str
EXCITOTOXICITY	causes	phenotype	0.72
LDHA	causes	gene	0.70
AMYLOID	inhibits	protein	0.70
GLUTAMATE EXCITOTOXICITY	causes	phenotype	0.70
GLUTAMATE EXCITOTOXICITY	inhibits	phenotype	0.70
TAU	phosphorylates	protein	0.70
NEURONS	stabilizes	cell_type	0.70
PRION	activates	protein	0.70
FERROPTOSIS	causes	phenotype	0.65
ACETYLCHOLINE	biomarker_for	phenotype	0.65
NEURONS	causes	cell_type	0.65
HIPPOCAMPUS	regulates	brain_region	0.65
PARKINSON'S DISEASE	interacts_with	disease	0.65
WHITE MATTER	produces	brain_region	0.65
WHITE MATTER	transports	brain_region	0.65
GFAP	transports	gene	0.65
PURKINJE CELLS	regulates	cell_type	0.65
PCSK9	targets	gene	0.65
GLAUCOMA	activates	disease	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
MICROGLIA	activates	cell_type	0.65
NEURONS	biomarker_for	cell_type	0.65
TDP-43	phosphorylates	gene	0.65
EPILEPSY	causes	disease	0.65
SYNAPTIC PLASTICITY	regulates	phenotype	0.65
VASCULAR DEMENTIA	causes	disease	0.65
ATG5	inhibits	gene	0.65
ATG5	activates	gene	0.65
LAMP1	activates	gene	0.65
NUCLEUS ACCUMBENS	interacts_with	brain_region	0.65
CHOLESTEROL	activates	phenotype	0.65
STROKE	produces	disease	0.65
WHITE MATTER	targets	brain_region	0.65
CHOLESTEROL	targets	phenotype	0.65
NEURONS	treats	cell_type	0.65
HUNTINGTON'S DISEASE	inhibits	disease	0.65
GLYCOLYSIS	causes	phenotype	0.60
COGNITIVE DECLINE	causes	phenotype	0.60
LACTATE	activates	phenotype	0.60
AXONS	inhibits	cell_type	0.56
CEREBRAL CORTEX	expressed_in	brain_region	0.55
HIPPOCAMPUS	depleted_in	brain_region	0.55
ASTROCYTES	depleted_in	cell_type	0.55
EXCITOTOXICITY	depleted_in	phenotype	0.55
NLRP3 INFLAMMASOME	implicated_in	pathway	0.55
TAU	depleted_in	protein	0.55
GPX4	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
OPTN	co_discussed	entity	0.50
PINK1	co_discussed	entity	0.50

Incoming (399)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
TAU	associated_with	protein	1.00
ASTROCYTES	associated_with	cell_type	1.00
AMYLOID	associated_with	protein	1.00
ALS	associated_with	disease	0.98
APOE	associated_with	gene	0.82
NF-KB	associated_with	protein	0.82
APP	associated_with	gene	0.82
ASTROCYTES	activates	cell_type	0.80
AKT	associated_with	gene	0.74
CASP3	associated_with	gene	0.74
SOD1	associated_with	gene	0.74
TARDBP	associated_with	gene	0.74
PARKINSON'S DISEASE	associated_with	disease	0.74
CYTOKINES	regulates	phenotype	0.70
ASTROCYTES	protects_against	cell_type	0.70
APOE	causes	gene	0.70
APOE	regulates	gene	0.70
APOE	destabilizes	gene	0.70
NEURODEGENERATION	treats	phenotype	0.70
AMYLOID	causes	protein	0.70
UBIQUITIN	associated_with	protein	0.66
MICROGLIA	associated_with	cell_type	0.66
ALS	causes	disease	0.66
BDNF	associated_with	gene	0.66
TNF	associated_with	gene	0.66
CELL DEATH	causes	phenotype	0.65
HIPPOCAMPUS	causes	brain_region	0.65
SLC7A11	regulates	gene	0.65
STING	causes	gene	0.65
TAU	regulates	protein	0.65
KETAMINE	activates	drug	0.65
GFAP	causes	gene	0.65
LIPID PEROXIDATION	inhibits	phenotype	0.65
KDM6B	regulates	gene	0.65
GLIAL FIBRILLARY ACIDIC PROTEIN	causes	biomarker	0.65
BDNF	protects_against	gene	0.65
BDNF	causes	gene	0.65
ROS	protects_against	phenotype	0.65
BIN1	causes	gene	0.65
PARKINSON'S DISEASE	regulates	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
ABCA7	exacerbates	gene	0.65
VPS35	transports	gene	0.65
TNF	regulates	gene	0.65
LRRK2	treats	gene	0.65
DEPRESSION	inhibits	disease	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
AXONAL DEGENERATION	activates	phenotype	0.65
MACROPHAGES	activates	cell_type	0.64

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLUTAMATE

Understanding Entity Pages

Wiki Pages (21)

Glutamate - Excitotoxicity and Neurodegeneration Biomarker

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Atypical Parkinsonism

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nimodipine-als

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway