protein

NMDA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

134Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for NMDA Receptor Subunit NR2B (GRIN2B)

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🔬 Protein Info

Gene Symbol	NMDA
Aliases	GRIN2B, GRIN1
Molecular Weight	166 kDa
Pathways	glutamate signaling, unfolded protein response, oxidative stress response, mitochondrial function, sphingolipid metabolism
GeneCards	NMDA
Human Protein Atlas	NMDA
Taxonomy	ID
Cell Ontology (CL)	CL:0000122
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Huntington, disease, epilepsy
Known Drugs/Compounds	memantine
Interactions	SLC17A7, PSD-95, TET2, ROS, VPS35, P2Y12
KG Connections	134 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NMDA["<b>NMDA</b>"]
    SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
    NMDA -->|"associated with"| SYNAPTOPHYSINSYP
    Memantine["Memantine"]
    Memantine -->|"activates"| NMDA
    Memantine -->|"inhibits"| NMDA
    GLUTAMATE["GLUTAMATE"]
    GLUTAMATE -->|"co discussed"| NMDA
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"co discussed"| NMDA
    ALZHEIMER_S["ALZHEIMER'S"]
    ALZHEIMER_S -->|"co discussed"| NMDA
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"co discussed"| NMDA
    style NMDA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (84)

Target	Relation	Type	Str
glutamate signaling	participates_in	pathway	0.85
PSD-95	associated_with	gene	0.75
neurons	expressed_in	cell_type	0.75
neurodegeneration	activates	disease	0.65
unfolded protein response	participates_in	pathway	0.65
oxidative stress response	participates_in	pathway	0.65
PSD-95	interacts_with	gene	0.65
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
epilepsy	associated_with	disease	0.60
stroke	associated_with	disease	0.60
SQSTM1	regulates	gene	0.60
Alzheimer's disease	regulates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
neurodegeneration	inhibits	disease	0.60
pyroptosis	participates_in	pathway	0.60
VPS35	interacts_with	gene	0.60
epilepsy	inhibits	disease	0.60
NMDAR	causes	gene	0.60
epilepsy	causes	disease	0.60
schizophrenia	causes	disease	0.60
stroke	regulates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
neuroinflammation	inhibits	disease	0.60
microglia	expressed_in	cell_type	0.60
NF-kB signaling	participates_in	pathway	0.60
neuroinflammation	activates	disease	0.60
PSD95	targets	gene	0.55
mitochondrial function	participates_in	pathway	0.55
sphingolipid metabolism	participates_in	pathway	0.55
neurotrophin signaling	participates_in	pathway	0.55
oligodendrocytes	expressed_in	cell_type	0.55
MAPK signaling	participates_in	pathway	0.55
SLC17A7	activates	gene	0.55
epilepsy	activates	disease	0.55
PSD95	expressed_in	gene	0.55
Alzheimer's disease	expressed_in	disease	0.55
tauopathy	expressed_in	disease	0.55
synaptic plasticity	participates_in	pathway	0.55
Alzheimer's disease	inhibits	disease	0.55
TET2	activates	gene	0.55
ROS	activates	gene	0.55
astrocytes	expressed_in	cell_type	0.55
P2Y12	activates	protein	0.50
AMPA RECEPTOR	activates	protein	0.50
NMDA RECEPTOR	activates	protein	0.50

Incoming (50)

Source	Relation	Type	Str
Memantine	activates	entity	0.70
Memantine	inhibits	entity	0.70
GAPDH	regulates	gene	0.60
HDAC6	regulates	gene	0.60
ISG15	regulates	gene	0.60
LAMP1	regulates	gene	0.60
LC3	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
MAPT	regulates	gene	0.60
memantine	targets	drug	0.60
APP	inhibits	gene	0.60
NLRP3	activates	gene	0.60
APOE	associated_with	gene	0.60
LRRK2	interacts_with	gene	0.60
CRH	associated_with	gene	0.60
EAAT2	inhibits	gene	0.60
AND	regulates	gene	0.60
AND	inhibits	gene	0.60
ABCA7	activates	gene	0.60
GABA	activates	gene	0.60
CCL2	activates	gene	0.60
LAMP2B	regulates	gene	0.60
BAK	activates	gene	0.55
BAX	activates	gene	0.55
JNK	activates	gene	0.55
ATP	activates	gene	0.55
NLGN1	interacts_with	gene	0.55
GLUTAMATE	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
AMYLOID	activates	gene	0.50
GENES	co_discussed	gene	0.50
PI3K	regulates	protein	0.50
Neurodegeneration	protects_against	disease	0.50
L-TYPE CALCIUM CHANNEL	inhibits	protein	0.50
GABA	inhibits	gene	0.50
VGLUT1	associated_with	gene	0.50
DREBRIN	interacts_with	protein	0.50
DREBRIN	associated_with	protein	0.50
DREBRIN	regulates	protein	0.50
GRIN2A	activates	gene	0.50
Neurodegeneration	inhibits	disease	0.50
ATP	co_expressed_with	protein	0.50
GRIN2D	co_expressed_with	protein	0.50
AQP4	co_expressed_with	gene	0.50
EAAT2	co_expressed_with	protein	0.50
APP	co_expressed_with	gene	0.50
BDNF	co_expressed_with	gene	0.50
LAMP2B	associated_with	gene	0.35

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Thalamocortical Synchrony Restoration via NMDA Modulation	0.542	neuroscience	Circuit-level neural dynamics in neurode
Cortico-Striatal Synchrony Restoration via NMDA Modulation	0.500	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Inspired by molecular dynamic simulation, exploring chemical constituents of alc [PMID:40166865]	Shinge J, Muthal A, Walhekar V, Bagul C,	Journal of biomolecular struct	2026
Cognitive loss after brain trauma results from sex-specific activation of synapt [PMID:40796363]	Arizanovska D, Bush GF, Dallera CA, Folo	Brain	2026
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil. [PMID:40994429]	Banke TG, Regan MC, Perszyk RE, Zhang L,	Brain	2026
GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and beha [PMID:41512078]	Ge Y, Tian T, Li B, Axerio-Cillies P, Ch	Sci Adv	2026
Zipper-interacting Protein Kinase Modulates Gene Expression Linked to Synaptic a [PMID:41526727]	Mei Y, Zheng L, He M, Wang L, Zhou Y et	Mol Neurobiol	2026
Multi-biofluid metabolomics coupled with gene network reveals stage-specific alt [PMID:41534821]	Cadaxo AS, Cotrin JC, Valente AP, Lopes	Brain Res	2026
Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mi [PMID:41675057]	Farsi Z, Nicolella A, Simmons SK, Shin W	iScience	2026
From synapse to system: mechanistic pathways of neural signaling dysfunction in [PMID:41799440]	Gupta R, Jha NK, Kumar N, Nagraik R, Rav	Front Cell Dev Biol	2026
Cellular Prion Protein Engages the N-Methyl-d-Aspartate Receptor through N- and [PMID:41860118]	Mayfield JE, Wang J, Tovell H, Taylor SS	Biochemistry	2026
Multisession epidural direct current stimulation of the auditory cortex mitigate [PMID:41747412]	Fernández Del Campo IS, Cebrián-León A,	Hearing research	2026

NMDA

Understanding Entity Pages

Summary

Wiki Pages (21)

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Clinical Management Guide for CBS/PSP

Corticobasal Syndrome (CBS)

CBS/PSP Supplements Guide

Atypical Parkinsonism

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nimodipine-als

Therapeutics

CBS/PSP Treatment Rankings

Alzheimer's Disease

Frontotemporal Dementia (FTD)

NTF4 Protein

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration