Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| E3 Ubiquitin Ligases | regulates | enzyme | 0.95 |
| UPS | regulates | pathway | 0.95 |
| Ubiquitin-Proteasome System | regulates | pathway | 0.95 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Purinergic signaling elements are correlated with coagulation players in periphe [PMID:35091759] | Schultz IC, Bertoni APS, Wink MR | J Mol Med (Berl) | 2022 | 1 |
| Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PMID:35386996] | Thompson RJ, Sayers I, Kuokkanen K, Hall | Front Allergy | 2021 | 1 |
| Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in m [PMID:25719930] | Todd JN, Poon W, Lyssenko V, Groop L, Ni | J Clin Endocrinol Metab | 2015 | 1 |
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |
| Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] | Nguyen DT, Mendoza K, Hall C, Tan C, Cha | Experimental neurology | 2026 | 0 |
| Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] | Mobasher M, Hone AJ, Pilzecker M, Bozic | Frontiers in immunology | 2026 | 0 |
| Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] | Costa SO, Silva IM, Chaves WF, Esteves A | The Journal of nutritional bio | 2026 | 0 |
| Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] | Cho Y, Kim HG, Kang JH, Oh ET, Park HJ | International journal of biolo | 2026 | 0 |
| Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinso [PMID:41761283] | Liu Z, Nie J, Li Y, Huang M, Chen Z et a | Transl Neurodegener | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617] | Dwortz MF, Hofmann HA, Curley JP | Res Sq | 2026 | 0 |
| Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] | Feng X, Jia M, Cai M, Zhu T, Hashimoto K | Molecular psychiatry | 2025 | 0 |
| The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292] | Wolf PMK, Hanke D, Singh VK, Keller HL, | Frontiers in immunology | 2025 | 0 |
| Gut Microbiota-Derived Lipopolysaccharides and Short-Chain Fatty Acids Regulate [PMID:41031863] | Maruyama D, Doan TNM, Tian X, Chaki T, Y | Ann N Y Acad Sci | 2025 | 0 |
| CSF ATP levels correlate with Alzheimer's disease severity and predict progressi [PMID:synthetic_4] | Unknown | JAMA Neurol | 2024 | 0 |
| Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290] | ["Yang Y", "Eguchi A", "Mori C", "Hashim | Journal of affective disorders | 2024 | 0 |
| Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] | Xia XM, Duan Y, Wang YP, Han RX, Dong YF | Acta pharmacologica Sinica | 2024 | 0 |
| Astrocyte phenotype switching controlled by purinergic receptor balance regulate [PMID:synthetic_1] | Unknown | Nature Neuroscience | 2023 | 0 |