Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Soluble TREM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Disorders | biomarker_for | disease | 0.85 |
| ARIA risk | protective_against | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 agonist antibodies | activates | drug | 0.90 |
| 41787076 | caused reductions in | paper | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha | 0.714 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| CSF Soluble TREM2 Fragment Ratio as Priming State Indicator | 0.689 | biomarkers | What biomarkers can reliably detect micr |
| Soluble TREM2 Sequestration and Recycling | 0.480 | neurodegeneration | TREM2 Therapeutic Strategy Post-INVOKE-2 |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917] | Choi C, Lee J, Park G, Namgoong S, Lee Y | iScience | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.95 · 2026-04-02
closed · Rounds: 4 · Score: 0.57 · 2026-04-01
Hypotheses and analyses mentioning Soluble TREM2 in their description or question text
No additional research found