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biomarker 1,043 words KG: sTREM2 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

sTREM2 (Soluble TREM2) - Microglial Biomarker

🔬 Protein Info
Gene SymbolsTREM2
Molecular Weight~25 kDa (soluble form)
UniProt IDQ9NZC2 (TREM2)
GeneTREM2
Protein NameSoluble TREM2
Cell Type ExpressionMicroglia
LigandsLipids, apolipoproteins, Aβ
Associated DiseasesAlzheimer's Disease
KG Connections10 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52TREM2-mediated microglial tau clearance enhancement
Score: 0.49APOE-TREM2 Interaction Modulation
Score: 0.48TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64

Related Analyses (14)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40

See Also (15)

trem2-therapeutics
therapeutic · Pages share 4 hypothesesTREM2-Targeting Therapies
therapeutic · Pages share 4 hypothesesTREM2 Modulator Therapy
therapeutic · Pages share 4 hypothesesTREM2 Agonist Therapy for Neurodegeneration
therapeutic · Pages share 4 hypothesesTREM2 Protein — Triggering Receptor Expressed on Myeloi
protein · Pages share 4 hypotheses

Knowledge Graph (10 edges)

sTREM2 biomarker_for Microglial Activation
sTREM2 involved_in Proteolytic Shedding
sTREM2 biomarker_for Neurodegenerative Disease
sTREM2 promotes Microglial Survival
sTREM2 enhances Microglial Phagocytosis
sTREM2 dampens Inflammatory Gene Expression
sTREM2 biomarker_for Alzheimer's Disease
sTREM2 biomarker_for Alzheimer's disease
sTREM2 associated_with Alzheimer's Disease
sTREM2 activates ERK1/2
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