Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synapse Pruning: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | associated_with | disease | 0.90 |
| microglia | causes | cell_type | 0.90 |
| MICROGLIA APOE LIPOPROTEINS | involved_in | protein | 0.85 |
| C1q | causes | protein | 0.70 |
| C3 | causes | protein | 0.70 |
| MHC-I | causes | protein | 0.70 |
| microglia | mediates | cell_type | 0.70 |
| C1q | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CX3CR1-TREM2 Integration for Synapse Pruning Normalization | 0.776 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
| H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from | 0.644 | neurodegeneration | TREM2 in Alzheimer's Disease: Mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.740
neurodegeneration | 2026-04-11 | 0 hypotheses
synaptic biology | 2026-04-07 | 17 hypotheses Top: 0.783
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurod [PMID:33603230] | Dong Y, D'Mello C, Pinsky W, Lozinski BM | Nature neuroscience | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Technology insight: imaging neurodegeneration in Parkinson's disease. [PMID:18382437] | Unknown | Nat Clin Pract Neurol | 2008 | 0 |
| MicroRNAs in neurodegeneration. [PMID:18662781] | Unknown | Curr Opin Neurobiol | 2008 | 0 |
| TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124] | Unknown | Prog Brain Res | 2008 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.65 · 2026-04-25
closed · Rounds: 4 · Score: 0.75 · 2026-04-21
closed · Rounds: 4 · Score: 0.51 · 2026-04-20
Hypotheses and analyses mentioning Synapse Pruning in their description or question text
No additional research found