concept

MHC-I

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MHC-I: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MHC-I is a concept in neurodegeneration research. Key relationships include: inhibits, activates, expressed in. Associated with Alzheimer, Alzheimer's disease, Breast Cancer. Connected to 93 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MHC-I
Key Genes/Proteins	Actin, Akt, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ApoE
Related Diseases	Als, Alzheimer, Alzheimer's disease, Alzheimer'S Disease
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    MHC_I["MHC-I"]
    MHC_I -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    MHC_I -->|"activates"| tau_pathology["tau pathology"]
    MHC_I -->|"causes"| selective_neurodegeneration["selective neurodegeneration"]
    MHC_I -->|"activates"| Alzheimer["Alzheimer"]
    MHC_I -->|"expressed in"| Ms["Ms"]
    MHC_I -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    MHC_I -->|"target for"| Carcinoma["Carcinoma"]
    MHC_I -->|"target for"| Cancer["Cancer"]
    MHC_I -->|"regulates"| Tumor["Tumor"]
    APOE["APOE"] -->|"activates"| MHC_I
    PNKPPROTEIN["PNKPPROTEIN"] -->|"upregulates"| MHC_I
    MLST8PROTEIN["MLST8PROTEIN"] -->|"upregulates"| MHC_I
    RGS4["RGS4"] -->|"upregulates"| MHC_I
    NOTCH1["NOTCH1"] -->|"upregulates"| MHC_I
    ApoE["ApoE"] -->|"regulates"| MHC_I
    SNRNP70["SNRNP70"] -->|"upregulates"| MHC_I
    FOXP2["FOXP2"] -->|"upregulates"| MHC_I
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| MHC_I
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| MHC_I

Outgoing (97)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.85
NEURODEGENERATION	associated_with	gene	0.85
TAU PATHOLOGY	associated_with	gene	0.85
Alzheimer's disease	causes	disease	0.80
CANCER	inhibits	gene	0.80
tau pathology	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
CD8	inhibits	gene	0.70
Immune Response	inhibits	pathway	0.70
tau pathology	biomarker_for	process	0.70
Synapse Pruning	causes	phenotype	0.70
synaptic pruning	biomarker_for	phenotype	0.70
selective neurodegeneration	causes	process	0.70
Colorectal Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Ovarian Cancer	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Tumor	causes	disease	0.65
Breast Cancer	activates	disease	0.65
Leukemia	inhibits	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
TAU PATHOLOGY	expressed_in	gene	0.60
IFNG	causes	gene	0.60
NLRC5	activates	gene	0.60
T Cell	activates	cell_type	0.60
Interferon Signaling	inhibits	pathway	0.60
Rb	inhibits	protein	0.60
G3BP1	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Akt	activates	protein	0.60
Pi3K	activates	protein	0.60
AND	inhibits	gene	0.60
AND	activates	gene	0.60
AND	regulates	gene	0.60
Lysosomal Degradation	regulates	pathway	0.60
APOE	expressed_in	gene	0.60
SELECTIVE NEURODEGENERATION	expressed_in	gene	0.60
TAU	expressed_in	gene	0.60
Immune Response	expressed_in	pathway	0.60
CANCER	therapeutic_target	gene	0.60

Incoming (55)

Source	Relation	Type	Str
PI3K/Akt signaling	downregulates	pathway	0.93
APOE	upregulates	gene	0.90
NPM1	downregulates	protein	0.85
APOE	activates	gene	0.85
NOTCH1	upregulates	gene	0.80
PNKPPROTEIN	upregulates	protein	0.80
MLST8PROTEIN	upregulates	protein	0.80
RGS4	upregulates	gene	0.80
NLRC5	regulates	gene	0.80
ApoE	regulates	protein	0.70
SNRNP70	upregulates	protein	0.70
FOXP2	upregulates	gene	0.70
CD8	expressed_in	gene	0.60
TRAIL	causes	gene	0.60
DNA	activates	gene	0.60
CD8	activates	gene	0.60
NPM1	activates	gene	0.60
CIITA	activates	gene	0.60
NLRC5	activates	gene	0.60
IFNG	causes	gene	0.60
GENES	inhibits	gene	0.60
IRF1	activates	gene	0.60
CDK5	inhibits	gene	0.60
AND	activates	gene	0.60
NBR1	regulates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOE4	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
HIF	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
CANCER	activates	gene	0.60
RNA	expressed_in	gene	0.60
PI3K	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
TAU	expressed_in	gene	0.60
SELECTIVE NEURODEGENERATION	expressed_in	gene	0.60
TAU PATHOLOGY	expressed_in	gene	0.60
APOE	expressed_in	gene	0.60
ALZHEIMER	activates	gene	0.60
RNA	activates	gene	0.60
TUMOR	activates	disease	0.50
Neurodegeneration	activates	disease	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
cancer	inhibits	disease	0.50
APOE4	inhibits	gene	0.50
APOE	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the selectivity of complement-mediated synaptic elimination in p

synaptic biology | 2026-04-07 | 17 hypotheses Top: 0.833

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows C1qa tags synapses for microglial elimination, but doesn't expla

closed · Rounds: 4 · Score: 0.75 · 2026-04-21

Related Research

Hypotheses and analyses mentioning MHC-I in their description or question text

No additional research found