entity

TDP-43 Phosphorylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 Phosphorylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections
1Hypotheses
0Analyses
0Outgoing
2Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Frontotemporal Dementia (FTD)

disease · 5230 words

Protein Aggregation Comparison in Neurodegeneration

mechanism · 4048 words

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

mechanism · 3471 words

GSK3B (Glycogen Synthase Kinase 3 Beta)

protein · 2976 words

GSK-3β

protein · 2976 words

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (4)

SourceRelationTypeStr
MAPK14phosphorylatesgene0.95
14-3-3θmediatesprotein0.85

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph 0.615 neurodegeneration What is the therapeutic window between i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine meth [PMID:39817908] Aikio M, Odeh HM, Wobst HJ, Lee BL, Chan Cell Rep 2025 0
Identification of energy metabolism-related biomarkers for risk prediction of he [PMID:36304554] Chen H, Jiang R, Huang W, Chen K, Zeng R Front Cardiovasc Med 2022 0
Calcium-dependent methylation by PRMT1 promotes erythroid differentiation throug [PMID:31541584] Liu MY, Hua WK, Chiou YY, Chen CJ, Yao C FEBS Lett 2020 0