gene

ywhaq

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ywhaq: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

10Outgoing

1Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	YWHAQ
Full Name	Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Theta
Chromosome	2p25.2
Protein Family	14-3-3 family
Function	encodes a protein of approximately 245 amino acids with a molecular weight of ~28 kDa[@berg1989].
Primary Expression	the central nervous system and has emerged as an important player in neurodegeneration, with roles in Alzheimer's disease, Parkinson's disease, and va
Molecular Weight	28 kDa
Amino Acids	245 aa
Pathways	MAPK, PI3K
UniProt ID	P27348
NCBI Gene ID	10971
Ensembl ID	ENSG00000108774
OMIM	609505
GeneCards	YWHAQ
Human Protein Atlas	YWHAQ
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ywhaq — AlphaFold P27348 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    N0["YWHAQ"]
    N1["Nuclear-Cytoplasmic Shuttling"]
    N0 -->|"regulates"| N1
    N2["TARDBP"]
    N0 -->|"binds"| N2
    N3["Tardbp Cytoplasmic Accumulation"]
    N0 -->|"promotes"| N3
    N4["Amyotrophic Lateral Sclerosis"]
    N0 -->|"mediates"| N4
    N5["Frontotemporal Dementia"]
    N0 -->|"mediates"| N5
    N6["Tdp-43 Phosphorylation"]
    N0 -->|"promotes"| N6
    N7["Tardbp Fragmentation"]
    N0 -->|"promotes"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N2 protein
    class N4 disease
    class N5 disease

Outgoing (10)

Target	Relation	Type	Str
Nuclear-Cytoplasmic Shuttling	regulates	process	0.95
TARDBP	binds	protein	0.90
Tardbp Cytoplasmic Accumulation	promotes	phenotype	0.90
Tdp-43 Phosphorylation	promotes	process	0.85
Tardbp Fragmentation	promotes	phenotype	0.85
Amyotrophic Lateral Sclerosis	mediates	disease	0.85
Frontotemporal Dementia	mediates	disease	0.85
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.80
Frontotemporal Dementia	biomarker_for	disease	0.80
benchmark_ot_ad_answer_key:YWHAQ	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:YWHAQ	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ywhaq

Understanding Entity Pages

Wiki Pages (8)

YWHAZ Gene

YWHAQ Gene

14-3-3 Proteins — Adapter and Scaffold Proteins

LRRK2-14-3-3 Interaction Network

YWHAQ Protein

TUBG1 Protein