gene

TFG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

1Analyses

1Outgoing

0Incoming

0Experiments

1Debates

Summary

Page for TFG Gene

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🧬 Gene Info

Gene Symbol	TFG
Aliases	TRK-Fused Gene
Chromosome	3p14.2
Protein Family	TFG family
Function	TFG (TRK-Fused Gene) is a multifunctional protein involved in cellular stress responses:
Subcellular Localization	Endoplasmic reticulum membrane
Amino Acids	400 aa
Exons	6
Pathways	NF-κB
UniProt ID	Q92734
NCBI Gene ID	10342
Ensembl ID	ENSG00000120708
GeneCards	TFG
Human Protein Atlas	TFG
ER Export	Facilitates protein export from endoplasmic reticulum
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TFG — AlphaFold Q92734 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TFG Gene

gene · 796 words

→

TFG Protein

protein · 2650 words

→

Pathway Diagram

graph TD
    TFG["TFG"]
    neurodegeneration["neurodegeneration"]
    TFG -->|"implicated_in"| neurodegeneration
    style TFG fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
ERES organization	regulates	mechanism	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.584

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

closed · Rounds: 4 · Score: 0.63 · 2026-04-13

Related Research

Hypotheses and analyses mentioning TFG in their description or question text

No additional research found