Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TGF-β anti-inflammatory signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ocular Immune Privilege Extension | 0.692 | neurodegeneration | Digital biomarkers and AI-driven early d |
| BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp | 0.536 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
| Microbiome-Derived Tryptophan Metabolite Neuroprotection | 0.427 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d | validation | inflammatory bowel disease | 0.900 | 0.00 | IL-10 knockout mice | proposed | N/A |
| Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated Neurotoxic | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gut-Brain Axis Pathogenesis in Parkinson's Disease — Mechanism and Int | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propagation | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut Barrier Signatures in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| SCFA-Mediated Neuroinflammation in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Myocardial Milieu Favors Local Differentiation of Regulatory T Cells. [PMID:36744467] | Delgobo M, Weiß E, Ashour D, Richter L, | Circ Res | 2023 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| [Not Available]. [PMID:29176281] | Unknown | Nihon Rinsho Men'eki Gakkai ka | 2017 | 1 |
| Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of col [PMID:27111280] | Saito T, Nishikawa H, Wada H, Nagano Y, | Nat Med | 2016 | 1 |
| Impact of TGF-β1 on tumor immune microenvironment and prognosis in colorectal li [PMID:41386216] | Wang S, He J, Liao Y, Li W, Zhang W, Kan | Cancer treatment and research | 2026 | 0 |
| ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marr [PMID:41482017] | Huang F, Zhu Z, Xing Q, Li M | Biochimie | 2026 | 0 |
| An integrative analysis of genetic factors reveals dysregulation of cytokines, i [PMID:41593604] | Patidar P, Prakash T | Thrombosis journal | 2026 | 0 |
| BMP4 dose dictates lineage specification bias in human periodontal ligament stem [PMID:41568233] | Li Y, Tang Q, Li L, Lin C, Guo M et al. | Front Bioeng Biotechnol | 2025 | 0 |
| TGFβ1 and SMAD3 Expression Are Associated With Survival After the Immune Checkpo [PMID:41187938] | Seto Z, Inomata M, Noguchi A, Kado T, Mu | Cancer reports (Hoboken, N.J.) | 2025 | 0 |
| Immunomodulatory and anti-inflammatory effects of agave fructans in atopic derma [PMID:41409292] | Rios-Carlos M, Jiménez M, Cervantes-Garc | Frontiers in immunology | 2025 | 0 |
| Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurod [PMID:40640940] | Wang N, Sun C, Yang Y | J Neuroinflammation | 2025 | 0 |
| Assessment and Characterization of Induced Alloantigen-Specific Regulatory T Cel [PMID:41303440] | Bulygin A, Fisher M, Kurilin V, Alrhmoun | International journal of molec | 2025 | 0 |
| Peritumoral administration of immunomodulatory antibodies as a triple combinatio [PMID:38296598] | ["Wright Q", "Sinha D", "Wells J", "Fraz | Journal for immunotherapy of c | 2024 | 0 |
| A review on immunomodulatory effects of BPA analogues. [PMID:37204436] | ["Kodila A", "Franko N", "Sollner Dolenc | Archives of toxicology | 2023 | 0 |
| Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocar [PMID:35626744] | ["Faber S", "Lahoti T", "Taylor E", "Lew | Cells | 2022 | 0 |
| Gene editing. [PMID:32641840] | Unknown | Nature biotechnology | 2020 | 0 |
| Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selecti [PMID:31727470] | ["Dolciami D", "Ballarotto M", "Gargaro | European journal of medicinal | 2020 | 0 |
| Single-cell reconstruction of the adult human heart during heart failure and rec [PMID:31915373] | ["Wang L", "Yu P", "Zhou B", "Song J", " | Nature cell biology | 2020 | 0 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 0 |
| The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for O [PMID:32947781] | ["Choudhary M", "Malek G"] | International journal of molec | 2020 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning TGF-β anti-inflammatory signaling in their description or question text
No additional research found