gene

FOXP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

515Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

FOXP3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 281 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXP3
Full Name	FOXP3 (Forkhead Box P3)
Chromosome	Xp11.23
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	Transcription factor modulation - no direct small molecule binding
Mechanism of Action	Transcription factor modulation - no direct small molecule binding
Druggability	Low (0.35)
Clinical Stage	Phase I
Amino Acids	431 aa
Pathways	Apoptosis, Complement, Hedgehog, Immune Response, Mtor
UniProt ID	A0A494BZV0
NCBI Gene ID	Search NCBI
GeneCards	FOXP3
Human Protein Atlas	FOXP3
Associated Diseases	ALZHEIMER, Als, Autoimmune, Cancer, Carcinoma
Known Drugs/Compounds	paeoniflorin, Paeoniflorin
Interactions	TGFB1, TNF, STAT3, STAT6, APOE, CCR6
SciDEX Target	View Target Profile (2 clinical trials)
KG Connections	515 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FOXP3 — AlphaFold A0A494BZV0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOXP3["FOXP3"] -->|"co discussed"| TNFA["TNFA"]
    FOXP3["FOXP3"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    FOXP3["FOXP3"] -->|"co discussed"| PRKAA1["PRKAA1"]
    FOXP3["FOXP3"] -->|"co discussed"| NR3C1["NR3C1"]
    FOXP3["FOXP3"] -->|"co discussed"| DRD2["DRD2"]
    FOXP3["FOXP3"] -->|"co discussed"| CHR2["CHR2"]
    TGFB1["TGFB1"] -->|"interacts"| FOXP3["FOXP3"]
    style FOXP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (366)

Target	Relation	Type	Str
Regulatory T Cell Differentiation	regulates	process	0.95
CD4(+) T Cells	expressed_in	cell_type	0.95
macrophage phagocytosis	promotes	process	0.95
Regulatory T Cell	expressed_in	cell_type	0.95
Regulatory T cells	expressed_in	cell_type	0.95
acute ischemic stroke	protects_against	disease	0.92
cargo metabolism	enhances	process	0.90
macrophage phagocytosis	enhances	process	0.90
cargo metabolism	regulates	process	0.90
acute ischemic stroke	therapeutic_target	disease	0.87
cargo metabolism	promotes	process	0.87
paeoniflorin	interacts_with	compound	0.85
immune response suppression	mediates	process	0.85
Inflammation	regulates	disease	0.85
Inflammation	activates	disease	0.85
Als	activates	disease	0.85
Macrophage phagocytosis	facilitates	process	0.80
Als	inhibits	disease	0.75
CD4	activates	gene	0.70
CD4	regulates	gene	0.70
INFLAMMATION	regulates	gene	0.70
GENES	inhibits	gene	0.70
IL-6	activates	gene	0.70
Immune Response	activates	pathway	0.70
neural stem cells	expressed_in	cell_type	0.70
MTOR	activates	gene	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65

Incoming (149)

Source	Relation	Type	Str
h-6a065252	targets_gene	hypothesis	0.90
LC3	regulates	entity	0.85
macroautophagy	regulates	process	0.85
macroautophagy	modulates	process	0.85
Paeoniflorin	binds	compound	0.85
macroautophagy	inhibits	process	0.82
h-6a065252	targets	hypothesis	0.80
CD4	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
JUN	regulates	gene	0.60
CD4	regulates	gene	0.60
TGFB1	regulates	gene	0.60
CD14	activates	gene	0.60
RORC	activates	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
CD14	regulates	gene	0.60
CD4	inhibits	gene	0.60
ACSL4	associated_with	gene	0.60
MMP9	activates	gene	0.60
TCF4	activates	gene	0.60
MYC	activates	gene	0.60
CD4	expressed_in	gene	0.60
LDLR	activates	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FOXP3

Understanding Entity Pages

Summary

Wiki Pages (21)

FOXP3 (Forkhead Box P3)

Adaptive Immunity in Neurodegeneration

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Biomarkers in Neurodegeneration

Biomarkers for Parkinson's Disease

CCR8 Gene

Cyclophosphamide

Biomarkers for Corticobasal Degeneration

Efferocytosis in Neurodegeneration

Biomarkers for Progressive Supranuclear Palsy

treg-regulatory-t-cell-therapy-parkinsons

HDAC7 Protein

Biomarker Discovery Framework for Neurodegenerative Diseases

MAP2K2 Gene

FOXP4 — Forkhead Box P4

Peripheral Immune System in Parkinson's Disease

Interleukin-2 Phase 2 (NCT06096090) — Immunomodulation for AD

Immune Drug Repurposing for Advanced Parkinson's Disease

Biomarkers in Parkinsonian Syndromes (NCT06501469)