gene

TGFB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

723Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

TGFB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 297 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TGFB1
Full Name	Transforming Growth Factor Beta 1
Chromosome	19q13.2
Protein Type	Ligand
Target Class	Ligand
Function	encodes Transforming Growth Factor Beta 1, a key cytokine with complex roles in neuroinflammation, neuroprotection, and synaptic plasticity
Mechanism of Action	Monoclonal antibodies neutralizing TGF-β1 or small molecule inhibitors of TGF-β signaling
Druggability	Low (0.44)
Clinical Stage	Phase III
Amino Acids	390 aa
Gene Type	Protein coding
Pathways	Autophagy, Immune Response, Mtor, Tgf-Β
UniProt ID	P01137
Ensembl ID	ENSG00000127616
GeneCards	TGFB1
Human Protein Atlas	TGFB1
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	curcumin, resveratrol
Interactions	FOXP3, AHR, IL10, FUNDC1, SMAD3, BNIP3L
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	723 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TGFB1 — AlphaFold P01137 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TGFB1["TGFB1"] -->|"interacts"| AHR["AHR"]
    TGFB1["TGFB1"] -->|"interacts"| IL10["IL10"]
    TGFB1["TGFB1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    TGFB1["TGFB1"] -->|"interacts"| FOXP3["FOXP3"]
    AHR_1["AHR"] -->|"interacts"| TGFB1["TGFB1"]
    IL10_2["IL10"] -->|"interacts"| TGFB1["TGFB1"]
    FOXP3_3["FOXP3"] -->|"co discussed"| TGFB1["TGFB1"]
    TNFA["TNFA"] -->|"co discussed"| TGFB1["TGFB1"]
    style TGFB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (395)

Target	Relation	Type	Str
Hepatic Stellate Cells	activates	cell_type	0.95
Fibrosis	contributes_to	disease	0.95
Hsc Activation	mediates	process	0.93
Vascular Remodelling	involved_in	process	0.90
HSC Activation	mediates	process	0.90
Cancer-Associated Fibroblasts	activates	cell_type	0.90
Tumor Fibrosis	associated_with	phenotype	0.90
Liver Fibrosis	contributes_to	disease	0.90
pulmonary artery smooth muscle cell proliferation	promotes	process	0.90
extracellular vesicles	expressed_in	cell_type	0.90
fibrosis	promotes	process	0.90
kidney fibrosis	promotes	phenotype	0.90
mitophagy	activates	pathway	0.90
Hsc Cell Line	activates	cell_type	0.88
Hepatic Stellate Cell	activates	cell_type	0.88
Fibroblast Activation	promotes	process	0.88
Myofibroblasts	associated_with	cell_type	0.85
angiogenesis	promotes	process	0.85
senescence	regulates	process	0.85
MICROGLIA	upregulates	cell_type	0.85
Cellular Senescence	regulates	phenotype	0.85
Type 2 Diabetes Mellitus	biomarker_for	disease	0.82
PLSCR3	activates	protein	0.80
EGR1	activates	protein	0.80
CCN2	regulates	gene	0.80
myofibroblasts	regulates	cell_type	0.80
Fibrosis	causes	disease	0.80
Ischemic Heart Disease	biomarker_for	disease	0.79
Pulmonary Arterial Hypertension	involved_in	disease	0.75
FOXP3(lo) non-Treg cells	promotes	cell_type	0.75
Als	activates	disease	0.75
Inflammation	regulates	disease	0.75
Tumor	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Als	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
IL10	associated_with	gene	0.70
MAP1LC3B	associated_with	gene	0.70
TREGS	activates	cell_type	0.70
Autophagy	associated_with	pathway	0.70
ATG	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
TNF	associated_with	gene	0.65
NRF2	activates	gene	0.65
Cardiac	regulates	disease	0.65
Ms	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65

Incoming (328)

Source	Relation	Type	Str
FOXO1	upregulates	gene	0.92
FOXO1	mediates	gene	0.90
Necroinflammation	upregulates	process	0.90
HIF-1Α	upregulates	gene	0.90
h-6a065252	targets_gene	hypothesis	0.90
h-f9c6fa3f	targets_gene	hypothesis	0.90
Plasmin Activation	activates	process	0.85
PLG	activates	protein	0.85
high glucose	upregulates	compound	0.85
Hepatocyte	expressed_in	cell_type	0.85
h-6a065252	targets	hypothesis	0.80
h-f9c6fa3f	targets	hypothesis	0.80
METHIONINE RESTRICTION	inhibits	biological_process	0.80
TNF	associated_with	gene	0.80
mesenchymal stem cell	associated_with	cell_type	0.75
ATG	associated_with	gene	0.70
GENES	associated_with	gene	0.70
MIRNAS	therapeutic_target	gene	0.70
GSK3B	associated_with	gene	0.65
TAU	associated_with	gene	0.65
C1QR	activates	protein	0.64
BNIP3	activates	gene	0.60
GOT1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
GPT	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BECLIN1	activates	gene	0.60
P62	associated_with	gene	0.60
FTH1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
JUNB	activates	gene	0.60
CD4	regulates	gene	0.60
FOXP3	regulates	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
BCL2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
KCNK5	associated_with	gene	0.60
PAH	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
IL6	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
NFKB1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
IL1RN	associated_with	gene	0.60
CDKN2A	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
P62	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TGFB1

Understanding Entity Pages

Summary

Wiki Pages (21)

TGFB1 — Transforming Growth Factor Beta 1

Creatine for Neuroprotection

Arsenic Exposure and Alzheimer's Disease Mechanism

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Biomarkers in Neurodegeneration

Biomarkers for Parkinson's Disease

Microbiome Metabolomics and SCFA Therapy for CBS/PSP

Biomarkers for Corticobasal Degeneration

Cellular Senescence Hypothesis in Parkinson's Disease

Biomarkers for Progressive Supranuclear Palsy

treg-regulatory-t-cell-therapy-parkinsons

Biomarker Discovery Framework for Neurodegenerative Diseases

tgf-beta-hs3st2-tau-axis

Immune Drug Repurposing for Advanced Parkinson's Disease

FOXP3 (Forkhead Box P3)

Biomarkers in Parkinsonian Syndromes (NCT06501469)

PRKCA — Protein Kinase C Alpha

Biomarker-Based Classification of Corticobasal Syndrome

Section 123: Microbiome-Gut-Brain Axis Interventions for CBS/PSP

Deep Brain Stimulation