gene

TGFB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

723Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

TGFB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 297 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TGFB1
Full Name	Transforming Growth Factor Beta 1
Chromosome	19q13.2
Protein Type	Ligand
Target Class	Ligand
Function	encodes Transforming Growth Factor Beta 1, a key cytokine with complex roles in neuroinflammation, neuroprotection, and synaptic plasticity
Mechanism of Action	Monoclonal antibodies neutralizing TGF-β1 or small molecule inhibitors of TGF-β signaling
Druggability	Low (0.44)
Clinical Stage	Phase III
Amino Acids	390 aa
Gene Type	Protein coding
Pathways	Autophagy, Immune Response, Mtor, Tgf-Β
UniProt ID	P01137
Ensembl ID	ENSG00000127616
GeneCards	TGFB1
Human Protein Atlas	TGFB1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	curcumin, resveratrol
Interactions	ACTB, AHR, AHSA1, ALZHEIMER, AND, APP
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	723 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TGFB1 — AlphaFold P01137 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TGFB1 — Transforming Growth Factor Beta 1

gene · 769 words

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Pathway Diagram

graph TD
    TGFB1["TGFB1"] -->|"interacts"| AHR["AHR"]
    TGFB1["TGFB1"] -->|"interacts"| IL10["IL10"]
    TGFB1["TGFB1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    TGFB1["TGFB1"] -->|"interacts"| FOXP3["FOXP3"]
    AHR_1["AHR"] -->|"interacts"| TGFB1["TGFB1"]
    IL10_2["IL10"] -->|"interacts"| TGFB1["TGFB1"]
    FOXP3_3["FOXP3"] -->|"co discussed"| TGFB1["TGFB1"]
    TNFA["TNFA"] -->|"co discussed"| TGFB1["TGFB1"]
    style TGFB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (385)

Target	Relation	Type	Str
Hepatic Stellate Cells	activates	cell_type	0.95
Fibrosis	associated_with	disease	0.95
Hsc Activation	mediates	process	0.93
HSC Activation	mediates	process	0.90
pulmonary artery smooth muscle cell proliferation	promotes	process	0.90
Cancer-Associated Fibroblasts	activates	cell_type	0.90
Vascular Remodelling	involved_in	process	0.90
EMT	enhances	pathway	0.90
Liver Fibrosis	contributes_to	disease	0.90
extracellular vesicles	expressed_in	cell_type	0.90
fibrosis	promotes	process	0.90
kidney fibrosis	promotes	phenotype	0.90
Tumor Fibrosis	associated_with	phenotype	0.90
mitophagy	activates	pathway	0.90
Fibroblast Activation	promotes	process	0.88
Hepatic Stellate Cell	activates	cell_type	0.88
Hsc Cell Line	activates	cell_type	0.88
senescence	regulates	process	0.85
MICROGLIA	upregulates	cell_type	0.85
angiogenesis	promotes	process	0.85
Cellular Senescence	regulates	phenotype	0.85
Myofibroblasts	associated_with	cell_type	0.85
Type 2 Diabetes Mellitus	biomarker_for	disease	0.82
Fibrosis	causes	disease	0.80
PLSCR3	activates	protein	0.80
Osimertinib resistance	enhances	disease	0.80
CCN2	regulates	gene	0.80
myofibroblasts	regulates	cell_type	0.80
EGR1	activates	protein	0.80
Ischemic Heart Disease	biomarker_for	disease	0.79
Tumor	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
Inflammation	regulates	disease	0.75
Als	associated_with	disease	0.75
FOXP3(lo) non-Treg cells	promotes	cell_type	0.75
Pulmonary Arterial Hypertension	involved_in	disease	0.75
Cancer	associated_with	disease	0.75
Als	activates	disease	0.75
C1Q deposition	inhibits	process	0.70
Autophagy	associated_with	pathway	0.70
ATG	associated_with	gene	0.70
TREGS	activates	cell_type	0.70
AUTOPHAGY	associated_with	gene	0.70
MAP1LC3B	associated_with	gene	0.70
IL10	associated_with	gene	0.70
Diabetes	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatitis	associated_with	disease	0.65
Carcinoma	activates	disease	0.65

Incoming (338)

Source	Relation	Type	Str
FOXO1	upregulates	gene	0.92
FOXO1	mediates	gene	0.90
h-f9c6fa3f	targets	hypothesis	0.90
h-6a065252	targets	hypothesis	0.90
Necroinflammation	upregulates	process	0.90
HIF-1Α	upregulates	gene	0.90
high glucose	upregulates	compound	0.85
PLG	activates	protein	0.85
Plasmin Activation	activates	process	0.85
Hepatocyte	expressed_in	cell_type	0.85
AHSA1-HSP90AA1 complex	associated_with	gene	0.80
METHIONINE RESTRICTION	inhibits	process	0.80
TNF	associated_with	gene	0.80
mesenchymal stem cell	associated_with	cell_type	0.75
GENES	associated_with	gene	0.70
ATG	associated_with	gene	0.70
MIRNAS	therapeutic_target	gene	0.70
GSK3B	associated_with	gene	0.65
TAU	associated_with	gene	0.65
C1QR	activates	protein	0.64
TGFB3	expressed_in	gene	0.60
BACE1	expressed_in	gene	0.60
VEGFA	expressed_in	gene	0.60
PDGFB	expressed_in	gene	0.60
BACE1	associated_with	gene	0.60
C3	regulates	gene	0.60
IGF1	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
CD8	therapeutic_target	gene	0.60
BCL2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
JUN	associated_with	gene	0.60
TP53	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
RAGE	therapeutic_target	gene	0.60
MYC	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
JUNB	activates	gene	0.60
IGF1R	associated_with	gene	0.60
BNIP3	activates	gene	0.60
STAT3	implicated_in	gene	0.60
TGFBR1	expressed_in	gene	0.60
SRC	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
HSP90AA1	implicated_in	gene	0.60
SMAD3	expressed_in	gene	0.60
AKT	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TGFB1 in their description or question text

No additional research found