entity

TIGHT JUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIGHT JUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections
6Hypotheses
1Analyses
2Outgoing
5Incoming
0Experiments
1Debates

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Outgoing (2)

TargetRelationTypeStr
intestinal barrier integrityregulatesprocess0.90
Blood-Brain Barrier Permeabilityregulatesphenotype0.85

Incoming (5)

SourceRelationTypeStr
CLDN5involved_inentity0.95
OCLNinvolved_inentity0.95
CLDN18involved_inprotein0.90
CLDN1encodesgene0.90
TJP1encodesgene0.90

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl 0.735 - What blood-brain barrier permeability ch
Matrix Metalloproteinase-9/TIMP-1 Ratio in CSF Identifies Pr 0.675 - What blood-brain barrier permeability ch
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl 0.640 - What blood-brain barrier permeability ch
Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drive 0.515 - What blood-brain barrier permeability ch
C1q-Alectinib Complexation Disrupts Tight Junction Integrity 0.445 molecular-biology Does Alectinib truly bind C1q directly w
Endocannabinoid-Mediated Tight Junction Stabilization 0.000 - Blood-brain barrier tight junction disru

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gut-Brain Axis Therapeutics for AD

neurodegeneration | 2026-04-01 | 4 hypotheses Top: 0.525

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can gut-brain axis modulation prevent or slow Alzheimer's disease pathology?

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning TIGHT JUNCTION in their description or question text

Endocannabinoid-Mediated Tight Junction Stabilization

Score: 0.000 · unknown disease · 2026-04-28

FAAH inhibitor and CB2 receptor agonist combination to enhance palmitoylethanolamide-mediated anti-inflammatory pathways