concept

TJP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TJP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TJP1 is a concept in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with ALS, Als, Ms. Connected to 77 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TJP1
Related Diseases	Brain Edema, transendothelial electrical resistance, Als, Stroke
Related Pathways	blood-brain barrier, BDNF-TrkB-PLC/IP3 pathway, oxidative stress response, autophagy pathway, ubiquitin-proteasome

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TJP1["TJP1"]
    TJP1 -->|"activates"| Als["Als"]
    TJP1 -->|"activates"| Stroke["Stroke"]
    TJP1 -->|"regulates"| Ms["Ms"]
    TJP1 -->|"activates"| ALS["ALS"]
    TJP1 -->|"activates"| Autophagy["Autophagy"]
    TJP1 -->|"activates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    TJP1 -->|"activates"| Proteasome["Proteasome"]
    TJP1 -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    BDNF_TrkB_PLC_IP3_pathway["BDNF-TrkB-PLC/IP3 pathway"] -->|"activates"| TJP1
    BECN1["BECN1"] -->|"activates"| TJP1
    CAV1["CAV1"] -->|"activates"| TJP1
    CLDN5["CLDN5"] -->|"activates"| TJP1
    HIF1A["HIF1A"] -->|"activates"| TJP1
    OCLN["OCLN"] -->|"activates"| TJP1
    ACTB["ACTB"] -->|"regulates"| TJP1
    ENO1["ENO1"] -->|"regulates"| TJP1
    TLR["TLR"] -->|"regulates"| TJP1
    EXOSOMES["EXOSOMES"] -->|"regulates"| TJP1

Outgoing (90)

Target	Relation	Type	Str
blood-brain barrier	involved_in	process	0.90
Brain Edema	associated_with	phenotype	0.85
transendothelial electrical resistance	regulates	phenotype	0.85
blood-brain barrier	participates_in	pathway	0.80
Cerebral Cortex	expressed_in	brain_region	0.80
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
endothelial cells	expressed_in	cell_type	0.70
Als	activates	disease	0.65
Stroke	activates	disease	0.65
Ms	regulates	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Autophagy	activates	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Proteasome	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Autophagy	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Toll-Like Receptor	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
ROS	activates	gene	0.60
STROKE	activates	gene	0.60
CAV1	activates	gene	0.60
CLDN5	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
OCLN	activates	gene	0.60
HIF1A	activates	gene	0.60
BECN1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Cerebrovascular	activates	pathway	0.60
TUBULIN	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
GJA1	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ACTB	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
SCIN	associated_with	gene	0.60

Incoming (107)

Source	Relation	Type	Str
KLF11	binds	entity	0.90
Gallic Acid	upregulates	compound	0.88
DTG	downregulates	drug	0.85
BDNF-TrkB-PLC/IP3 pathway	activates	pathway	0.80
BECN1	activates	gene	0.60
CAV1	activates	gene	0.60
CLDN5	activates	gene	0.60
HIF1A	activates	gene	0.60
OCLN	activates	gene	0.60
ACTB	regulates	gene	0.60
ENO1	regulates	gene	0.60
TLR	regulates	gene	0.60
EXOSOMES	regulates	gene	0.60
TRAF6	regulates	gene	0.60
OGT	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ROS	activates	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
SCIN	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
VIM	associated_with	gene	0.60
H2AX	regulates	gene	0.60
AND	activates	gene	0.60
STROKE	activates	gene	0.60
LAMP1	associated_with	gene	0.60
GJA1	regulates	gene	0.60
TUBULIN	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
VIMENTIN	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
ATG14	regulates	gene	0.60
GAPDH	regulates	gene	0.60
UVRAG	associated_with	gene	0.60
CASP3	regulates	gene	0.60
BECN1	regulates	gene	0.60
WT1	associated_with	gene	0.60
AND	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
STK11	associated_with	gene	0.60
CDC42	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
FAS	activates	gene	0.60
HMGCS2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TJP1

Understanding Entity Pages

Summary

Wiki Pages (5)

pard3

Blood-Brain Barrier Dysfunction Pathway

Brain Capillary Endothelial Cells