gene

CLDN5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLDN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

381Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

CLDN5 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, co discussed. Associated with ALS, Als, Brain Arteriovenous Malformations. Connected to 121 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CLDN5
Full Name	Claudin-5
Chromosome	22q11.21
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Tight junction protein modulation - no established druggable mechanisms
Mechanism of Action	Tight junction protein modulation - no established druggable mechanisms
Primary Expression	Brain endothelial cells, Tight junctions of blood-brain barrier
Druggability	Undruggable (0.20)
Clinical Stage	Approved
Amino Acids	218 aa
Exons	4
Pathways	Cerebrovascular
UniProt ID	O00511
NCBI Gene ID	9079
Ensembl ID	ENSG00000184113
OMIM	602507
GeneCards	CLDN5
Human Protein Atlas	CLDN5
Associated Diseases	ALS, Brain Edema, Stroke, blood-retinal barrier integrity, neurodegeneration
Known Drugs/Compounds	curcumin, resveratrol
Interactions	OCLN, CAV1, HIF1A, IL23A, BECN1, IL6
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Vascular-Glial Interface Restoration
KG Connections	381 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLDN5 — AlphaFold O00511 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CLDN5["CLDN5"]
    CLDN5 -->|"encodes"| CLAUDIN5["CLAUDIN5"]
    CLDN5 -->|"encodes"| Claudin_5["Claudin-5"]
    CLDN5 -->|"activates"| Stroke["Stroke"]
    CLDN5 -->|"inhibits"| Als["Als"]
    CLDN5 -->|"target for"| Ms["Ms"]
    CLDN5 -->|"inhibits"| ALS["ALS"]
    h_7a8d7379["h-7a8d7379"] -->|"target for"| CLDN5
    H3K27me3["H3K27me3"] -->|"inhibits"| CLDN5
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| CLDN5
    OCLN["OCLN"] -->|"activates"| CLDN5
    BECN1["BECN1"] -->|"activates"| CLDN5
    CXCL2["CXCL2"] -->|"inhibits"| CLDN5
    IL6["IL6"] -->|"inhibits"| CLDN5
    ATF4["ATF4"] -->|"target for"| CLDN5
    PPP1R15A["PPP1R15A"] -->|"target for"| CLDN5

Outgoing (249)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Blood-Brain Barrier Integrity	component_of	phenotype	0.95
TIGHT JUNCTION	involved_in	entity	0.95
Blood-Brain Barrier Integrity	regulates	phenotype	0.95
Blood-Retinal Barrier Integrity	promotes	phenotype	0.95
BLOOD-BRAIN BARRIER	involved_in	entity	0.95
Blood-Brain Barrier	involved_in	process	0.95
Blood-Brain Barrier Integrity	involved_in	phenotype	0.90
Brain Arteriovenous Malformations	biomarker_for	disease	0.90
blood-retinal barrier integrity	associated_with	phenotype	0.90
BBB	regulates	process	0.90
Tight Junctions	involved_in	process	0.85
Blood-Brain Barrier Disruption	involved_in	process	0.85
Brain Edema	associated_with	phenotype	0.85
Glioma Progression	downregulates	process	0.85
MICROGLIA	expressed_in	entity	0.85
Cerebrovascular Disease	therapeutic_target	disease	0.83
CLAUDIN5	encodes	protein	0.80
Brain Arteriovenous Malformations	downregulates	disease	0.80
Blood-Brain Barrier Disruption	biomarker_for	phenotype	0.80
Cerebral Cortex	expressed_in	brain_region	0.80
blood-brain barrier integrity	mediates	phenotype	0.80
Stroke	biomarker_for	disease	0.80
Glioma	downregulates	disease	0.80
claudin_5	encodes	protein	0.80
Glioblastoma	biomarker_for	disease	0.75
Claudin-5	encodes	protein	0.70
DRP1	inhibits	gene	0.70
DRP1	protects_against	gene	0.70
OCLN	co_mentioned_with	gene	0.70
Glioblastoma Multiforme	suppresses	disease	0.70
Blood-Brain Barrier	activates	pathway	0.70
neurons	promotes	cell_type	0.70
neurons	expressed_in	cell_type	0.70
blood_brain_barrier	maintains	structure	0.70
Stroke	activates	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
ALS	activates	disease	0.65
Depression	activates	disease	0.65
Inflammation	activates	disease	0.65
STROKE	accumulates_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Vascular Dementia	interacts_with	disease	0.65

Incoming (132)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Brain Arteriovenous Malformations	downregulates	disease	0.95
Autophagy	regulates	process	0.95
DTG	downregulates	entity	0.95
BRAIN ARTERIOVENOUS MALFORMATIONS	downregulates	entity	0.95
Brain Microvascular Endothelial Cells	expressed_in	cell_type	0.92
CAV1	mediates	protein	0.90
RUPTURED BRAIN ARTERIOVENOUS MALFORMATIONS	downregulates	entity	0.90
Drp1 Inhibition	upregulates	mechanism	0.90
ER STRESS	downregulates	entity	0.90
h-7a8d7379	targets_gene	hypothesis	0.90
CAV1	regulates	gene	0.85
Hypoxia	causes	process	0.85
Cavernomas	associated_with	disease	0.85
DRP1 inhibition	upregulates	drug	0.85
Autophagy	degrades	process	0.85
h-7a8d7379	targets	hypothesis	0.80
CAVERNOMAS	associated_with	entity	0.80
LICOCUMARONE	stabilizes	drug	0.80
Endoplasmic Reticulum Stress	downregulates	process	0.80
autophagy	degrades	process	0.80
LC3	mediates	entity	0.75
H3K27me3	inhibits	process	0.70
AUTOPHAGY	regulates	pathway	0.64
OCLN	activates	gene	0.60
BECN1	activates	gene	0.60
CXCL2	inhibits	gene	0.60
IL6	inhibits	gene	0.60
ATF4	therapeutic_target	gene	0.60
PPP1R15A	therapeutic_target	gene	0.60
IL12B	inhibits	gene	0.60
XBP1	therapeutic_target	gene	0.60
CXCL1	inhibits	gene	0.60
DDIT3	therapeutic_target	gene	0.60
CAV1	activates	gene	0.60
ATF4	activates	gene	0.60
GAL	activates	gene	0.60
TLR2	activates	gene	0.60
ZO1	activates	gene	0.60
XBP1	activates	gene	0.60
HSPA5	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
IL23A	inhibits	gene	0.60
OCLN	inhibits	gene	0.60
BECN1	regulates	gene	0.60
ICAM1	inhibits	gene	0.60
ABCD2	activates	gene	0.60
ABCD1	inhibits	gene	0.60
HSPA5	therapeutic_target	gene	0.60
PERK	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Vascular-Glial Interface Restoration	0.544	neurodegeneration	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (2)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CLDN5

Understanding Entity Pages

Summary

Wiki Pages (21)

CLDN5 — Claudin-5

Blood-Brain Barrier Dysfunction in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

bbb-transport-mechanisms

Blood-Brain Barrier Breakdown in Neurodegeneration

blood-brain-barrier-endothelial-cells

Blood-Based Biomarkers for Neurodegeneration

Blood Microbial Signatures in Parkinson's Disease

CAV1

Blood-Brain Barrier

Neurovascular Unit Dysfunction Hypothesis in Parkinson's Disease

Blood-Brain Barrier Penetration Technologies Investment Landscape

BBB-Transcytosis Shuttle for Episodic CNS PROTAC Delivery

Blood-Brain Barrier in 4R-Tauopathies

Brain Venous Endothelial Cells

Blood-Brain Barrier Breakdown as Primary Disease Driver

Blood-Brain Barrier Dysfunction Pathway

Blood p-Tau217 as a Clock for Alzheimer's Disease Onset Timing