Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2-DAP12 microglial signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | participates_in | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-mediated microglial tau clearance enhancement | 0.487 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
| TREM2 Conformational Stabilizers for Synaptic Discrimination | 0.411 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Microglia in neurodegeneration. [PMID:30258234] | Hickman S, Izzy S, Sen P, Morsett L, El | Nat Neurosci | 2018 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| How neuroinflammation contributes to neurodegeneration. [PMID:27540165] | Ransohoff RM | Science | 2016 | 1 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |
| Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750] | Yang X, Zhao Y, Liu W, Feng J, Wu X et a | J Ethnopharmacol | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407] | Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e | Kaohsiung J Med Sci | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876] | Chen F, Xue Y, Ma X, Chen L, Shao Z et a | Adv Sci (Weinh) | 2026 | 0 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven G, Gezegen H, Şahin E, Samancı B, | Acta neurologica Belgica | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412] | Villani A, Wittmann J, Wyss T, Mallona I | Commun Biol | 2026 | 0 |