gene

TRPC7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPC7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TRPC7 encodes a calcium-permeable cation channel involved in neuronal calcium signaling, synaptic plasticity, and neurodegenerative disease processes.

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🧬 Gene Info

Gene Symbol	TRPC7
Full Name	Transient Receptor Potential Cation Channel Subfamily C Member 7
Chromosome	5q32
Protein Type	Channel
Function	encodes a calcium-permeable non-selective cation channel that belongs to the TRPC (Transient Receptor Potential Canonical) family of ion channels.
Primary Expression	various tissues including brain, heart, lung, and skin, where it participates in diverse physiological processes ranging from neuronal signaling to ca
Amino Acids	793 aa
UniProt ID	Q9HCX6
NCBI Gene ID	16409
Ensembl ID	ENSG00000069020
GeneCards	TRPC7
Human Protein Atlas	TRPC7
N-terminal domain	Contains four ankyrin repeats involved in protein-protein interactions and channel regulation
Pre-S6 domain	Contains multiple phosphorylation sites
Transmembrane domain	Six transmembrane segments (S1-S6) forming the pore structure
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRPC7 — AlphaFold Q9HCX6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRPC7

gene · 1911 words

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Pathway Diagram

graph TD
    TRPC7["TRPC7"]
    neurodegeneration["neurodegeneration"]
    TRPC7 -->|"implicated_in"| neurodegeneration
    style TRPC7 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPC7 in their description or question text

No additional research found