Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPV5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TRPV5 encodes a highly calcium-selective ion channel essential for calcium homeostasis, with roles in neuronal calcium regulation and neurodegenerative diseases.
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| Gene Symbol | TRPV5 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily V Member 5 |
| Chromosome | 7q33 |
| Protein Type | Channel |
| Function | encodes a highly calcium-selective ion channel that serves as the primary entry pathway for transcellular calcium transport in epithelial tissues. |
| Primary Expression | various regions including the hippocampus, cerebral cortex, and [cerebellum](/brain-regions/cer |
| Amino Acids | 730 aa |
| UniProt ID | Q9NHA2 |
| NCBI Gene ID | 56802 |
| Ensembl ID | ENSG00000165102 |
| GeneCards | TRPV5 |
| Human Protein Atlas | TRPV5 |
| N-terminal domain | Contains six ankyrin repeat domains (ARD), which are involved in protein-protein interactions and channel regulation |
| Pre-sensor loop | A distinctive feature of TRPV channels between transmembrane segments S1-S4 that functions as a voltage sensor |
| Transmembrane domain | Six transmembrane helices (S1-S6) with a pore loop between S5 and S6 forming the ion selectivity filter |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TRPV5["TRPV5"]
neurodegeneration["neurodegeneration"]
TRPV5 -->|"implicated_in"| neurodegeneration
style TRPV5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRPV5 in their description or question text
No additional research found