Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRPV6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TRPV6 encodes a highly calcium-selective channel with roles in intestinal calcium absorption, neuronal calcium signaling, and neurodegenerative disease processes.
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| Gene Symbol | TRPV6 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily V Member 6 |
| Chromosome | 2q37 |
| Protein Type | Channel |
| Function | encodes a highly calcium-selective ion channel that serves as the primary pathway for calcium absorption in the intestinal epithelium[@peng2000b]. |
| Primary Expression | multiple neuronal populations throughout the brain[@boehmer2008]: |
| Amino Acids | 725 aa |
| UniProt ID | Q9H1D0 |
| NCBI Gene ID | 9903 |
| Ensembl ID | ENSG00000165283 |
| GeneCards | TRPV6 |
| Human Protein Atlas | TRPV6 |
| Ankyrin repeat domain (ARD) | Six ankyrin repeats at the N-terminus for protein interactions |
| Transmembrane domain | Six transmembrane segments (S1-S6) with a pore-forming loop between S5 and S6 |
| TRP domain | Conserved TRP box motif in the C-terminus involved in gating |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TRPV6["TRPV6"]
neurodegeneration["neurodegeneration"]
TRPV6 -->|"implicated_in"| neurodegeneration
style TRPV6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRPV6 in their description or question text
No additional research found